Badar U. Jan

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Autonomic inputs from the sympathetic and parasympathetic nervous systems, as measured by heart rate variability (HRV), have been reported to correlate to the severity injury and responses to infectious challenge among critically ill patients. In addition, parasympathetic/vagal activity has been shown experimentally to exert anti-inflammatory effects via(More)
OBJECTIVE To determine whether the acute anti-inflammatory influence of epinephrine (EPI) extends to changes in heart rate variability (HRV) induced by the prototypical inflammatory stimulus, endotoxin (lipopolysaccharide [LPS]). SUMMARY BACKGROUND DATA HRV reflects fluctuating cardiac autonomic inputs and is acutely reduced during the systemic(More)
Septic shock is a leading cause of hospital deaths in the United States. A system to detect initial immune response to an infection could allow for treatment before septic shock occurs, which would save many lives. Here, we demonstrate the analysis of beat-to-beat heart rate intervals using the Hilbert-Huang transform (HHT) as a method of detection of the(More)
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