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Excessive signaling from the Wnt pathway is associated with numerous human cancers. Using a high throughput screen designed to detect inhibitors of Wnt/β-catenin signaling, we identified a series of acyl hydrazones that act downstream of the β-catenin destruction complex to inhibit both Wnt-induced and cancer-associated constitutive Wnt signaling via(More)
Excessive signaling from the Wnt pathway is associated with numerous human cancers. Using a high throughput screen designed to detect inhibitors of Wnt/b-catenin signaling, we identified a series of acyl hydrazones that act downstream of the b-catenin destruction complex to inhibit both Wnt-induced and cancer-associated constitutive Wnt signaling via(More)
HER2(+) breast cancer is currently treated with chemotherapy plus anti-HER2 inhibitors. Many patients do not respond or relapse with aggressive metastatic disease. Therefore, there is an urgent need for new therapeutics that can target HER2(+) breast cancer and potentiate the effect of anti-HER2 inhibitors, in particular those that can target(More)
This article examines the operational characteristics of the injected pultrusion (IP) process using a bench-scale unit. The distributed, nonlinear nature of the process makes routine process operations and quality control difficult. In our prior work [1], a 3-dimensional dynamic model based on mass, momentum and energy transport was developed. This(More)
This article describes a set of virtual and real experiments used to supplement an undergraduate course in process control. By integrating laboratory exercises with the course, students observe the close relationship between theory and application. The open-ended experiments encourage creativity and allow students to explore various control system design(More)
In this tutorial, we discuss approaches to control of one or more primary variables in a process using secondary measurements. This approach is useful when the primary variable is not easily measured, or has large time delays or lags associated with it. It is also useful when the secondary measurements contain information about disturbances that affect the(More)
Production of cold active lipase by semisolid state fermentation involves the use of agroindustrial residues. In the present study, semisolid state fermentation was carried out for the production of cold active lipase using Micrococcus roseus, isolated from soil samples of Gangotri glaciers, Western Himalayas. Among various substrate tested, groundnut oil(More)
BACKGROUND Human immunodeficiency virus (HIV) infection is one of the most debilitating conditions which have affected nearly 32 million people across the globe. Antiretroviral therapy (ART) is the standard care given to the HIV positive individuals. But the patient adherence to ART is found to be very less as per previous studies. Complementary and(More)