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Lipases are glycerol ester hydrolases that catalyze the hydrolysis of triglycerides to free fatty acids and glycerol. Lipases catalyze esterification, interesterification, acidolysis, alcoholysis and aminolysis in addition to the hydrolytic activity on triglycerides. The temperature stability of lipases has regarded as the most important characteristic for(More)
Excessive signaling from the Wnt pathway is associated with numerous human cancers. Using a high throughput screen designed to detect inhibitors of Wnt/β-catenin signaling, we identified a series of acyl hydrazones that act downstream of the β-catenin destruction complex to inhibit both Wnt-induced and cancer-associated constitutive Wnt signaling via(More)
Excessive signaling from the Wnt pathway is associated with numerous human cancers. Using a high throughput screen designed to detect inhibitors of Wnt/b-catenin signaling, we identified a series of acyl hydrazones that act downstream of the b-catenin destruction complex to inhibit both Wnt-induced and cancer-associated constitutive Wnt signaling via(More)
HER2(+) breast cancer is currently treated with chemotherapy plus anti-HER2 inhibitors. Many patients do not respond or relapse with aggressive metastatic disease. Therefore, there is an urgent need for new therapeutics that can target HER2(+) breast cancer and potentiate the effect of anti-HER2 inhibitors, in particular those that can target(More)
Staphylococcus epidermidis isolated from spoiled frozen marine fish samples exhibited optimum lipase activity of 8.1 U within 72 h in batch fermentation. Inducible effect of different sugars, nitrogen sources, salts and metal ions were studied on enzyme production. Trybutyrin induced the enzyme production by twofold. Addition of lactose in the production(More)
All transducers used in biological sensing suffer from fouling resulting from nonspecific binding of protein molecules to the device surface. The acoustic-streaming phenomenon, which results from the fluid motion induced by high-intensity sound waves, can be used to remove these nonspecifically bound proteins to allow more accurate determinations and reuse(More)
This article examines the operational characteristics of the injected pultrusion (IP) process using a bench-scale unit. The distributed, nonlinear nature of the process makes routine process operations and quality control difficult. In our prior work [1], a 3-dimensional dynamic model based on mass, momentum and energy transport was developed. This(More)
This article describes a set of virtual and real experiments used to supplement an undergraduate course in process control. By integrating laboratory exercises with the course, students observe the close relationship between theory and application. The open-ended experiments encourage creativity and allow students to explore various control system design(More)
In this tutorial, we discuss approaches to control of one or more primary variables in a process using secondary measurements. This approach is useful when the primary variable is not easily measured, or has large time delays or lags associated with it. It is also useful when the secondary measurements contain information about disturbances that affect the(More)