• Publications
  • Influence
The Fun30 Chromatin Remodeler Fft3 Controls Nuclear Organization and Chromatin Structure of Insulators and Subtelomeres in Fission Yeast
In eukaryotic cells, local chromatin structure and chromatin organization in the nucleus both influence transcriptional regulation. At the local level, the Fun30 chromatin remodeler Fft3 is essentialExpand
  • 43
  • 10
The inner nuclear membrane proteins Man1 and Ima1 link to two different types of chromatin at the nuclear periphery in S. pombe
Metazoan chromatin at the nuclear periphery is generally characterized by lowly expressed genes and repressive chromatin marks and presents a sub-compartment with properties distinct from the nuclearExpand
  • 53
  • 3
Regulating retrotransposon activity through the use of alternative transcription start sites
Retrotransposons, the ancestors of retroviruses, have the potential for gene disruption and genomic takeover if not kept in check. Paradoxically, although host cells repress these elements byExpand
  • 16
  • 2
  • PDF
Transcriptional regulation at the yeast nuclear envelope
The spatial organization of the genome inside the nucleus affects many nuclear processes, such as DNA replication, DNA repair, and gene transcription. In metazoans, the nuclear periphery harborsExpand
  • 25
  • 1
Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linkedExpand
  • 1
Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization
Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, formingExpand
Regulating retrotransposons via alternative transcription start sites
and last paragraph of the intro, The claim that this is a new mechanism of retrotransposon regulation by transcription start site control is not true. The authors are apparently unaware of the workExpand