Babak Jamali

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Drug enantiomers can have biologically distinct interactions within the biological system and consequently different pharmacological or toxicological effects. Development of a better and safer drug product may be considered if one of the enantiomers has a significantly better effect/side effect ratio than the other. Investigation of the single enantiomers(More)
The application of high throughput experimentation (HTE) in protein purification process development has created an analytical bottleneck. Recently, a new label-free and non-invasive methodology for analyzing multicomponent protein mixtures by means of spectral measurements was presented. Analytics based on the methodology was shown to increase analytical(More)
— This paper presents a wireless synchronization receiver using sub-8psec pulses. A novel self-mixing technique is introduced to detect low-power picosecond impulses and extract the repetition rate with a low timing jitter. The chip is fabricated in a 0.13µm SiGe BiCMOS process and achieves a time transfer accuracy of 376fsec. The receiver, which is(More)
The objective of present study was to evaluate the impact of time of application of nitric oxide (NO) on mineral composition of strawberry ‘Selva’ plants under saline conditions. Well-rooted daughter plants were planted in 3L plastic pots filled with 1:1 (v/v) ratio of peat moss and perlite and grown under the greenhouse conditions (21 ± 2/17 ± 2°C and RH =(More)
A simple and sensitive method has been developed and validated for purity determination of FF-MAS (also known as (3beta,20R)-4,4-dimethylcholesta-8,14,24-trien-3-ol an endogenous substance usually present in the pre-ovulatory follicular fluid) at very low concentrations (200 ng per unit) in pharmaceutical formulations containing RECOMBUMIN (recombinant(More)
A dual CD-CE method for chiral separation of enantiomers of pioglitazone, rosiglitazone and balaglitazone was investigated for the purpose of optimizing the chiral separation. In a previous work a dual CD chiral CE method was used for investigation of glitazone compounds in drug substance and pharmaceutical formulation and the studies showed that all(More)
A selective, sensitive and robust capillary electrophoresis (CE) method has been developed and validated for multi analysis of ragaglitazar (also known as NNC 61-0029 or DRF 2725) and its counter ion arginine in Active Pharmaceutical Ingredients (API) and low-dose tablets (0.5, 1.0 and 2.0 mg). The method covers a total number of 12 analyses for the API and(More)
A high speed, selective, and robust capillary electrophoresis (CE) method with high capacity was developed and validated for determination of assay of 1,4-dideoxy-1,4-imino-D-arabinitol in active pharmaceutical ingredients, solutions, and tablets during the development work at preclinical and Phase I and II clinical studies.(More)