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The neuromuscular system of Drosophila has been widely used in studies on synaptic development. In the embryo, the cellular components of this model system are well established, with uniquely identified motoneurons displaying specific connectivity with distinct muscles. Such knowledge is essential to analyzing axon guidance and synaptic matching mechanisms(More)
Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits alphaPS1, alphaPS2, and betaPS during embryonic axogenesis. Furthermore,(More)
Toll, a transmembrane molecule with extracellular leucine-rich repeats, is dynamically expressed by the Drosophila embryonic musculature. Growth cones of RP3 and other motoneurons normally grow past Toll-positive muscle cells and innervate more distal muscle cells, which have down-regulated their Toll expression. In this study, we show that reciprocal(More)
  • B Flachs, S Asano, S H Dhong, P Hofstee, G Gervais, R Kim +21 others
  • 2002
The Synergistic Processor Element (SPE) is the first implementation of a new processor architecture designed to accelerate media and streaming workloads. Area and power efficiency are important enablers for multi-core designs that take advantage of parallelism in applications [2]. The architecture reduces area and power by solving scheduling problems such(More)
Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the(More)
The Synergistic Processing Element (SPE) is a processor designed to accelerate media and streaming workloads [1]. The Local Store (LS) unit in the SPE is a local memory comprised of several macros performing: (1) load/stores, (2) transactions for DMA, and (3) instruction fetches into an instruction line buffer (ILB). Because the LS occupies one-third of the(More)
The heterogeneous and dynamic tumor microenvironment has significant impact on cancer cell proliferation, invasion, drug response, and is probably associated with entering dormancy and recurrence. However, these complex settings are hard to recapitulate in vitro. In this study, we mimic different restriction forces that tumor cells are exposed to using a(More)
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