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Synthesis and biological properties of novel brefeldin A analogues.
New brefeldin A (1) analogues were obtained by introducing a variety of substituents at C15. Most of the analogues exhibited significant biological activity. (15R)-Trifluoromethyl-nor-brefeldin AExpand
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Otofaji ve kanser (Autophagy and cancer)
Otofaji, mayadan insana kadar olan tum okaryotik hucrelerde korunmus olan temel bir hucresel stres yanitidir. Hucre icerisinde, uzun omurlu proteinlerin, yanlis katlanmis ya da birikim olusturmusExpand
Functional and Kinetic studies of COPI machinery
Abstract In this study, different aspects of vesicular transport in the early secretory pathway have been investigated. Although an earlier study showed an effect upon the down regulation of β-COPExpand