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BACKGROUND AND OBJECTIVES Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis. METHODS Using(More)
Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables(More)
Introduction Neuromyelitis optica (NMO) is an immune-mediated disorder of the central nervous system (CNS) in which the optic nerves and the spinal cord are preferentially involved. 1 The disease-specific serum immunoglobu-lin (Ig)G targeting the astrocyte water channel aqua-porin-4 (AQP4) 2,3 has facilitated differentiation of NMO from multiple sclerosis(More)
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