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Objective: To evaluate the efficacy of surfactant and inhaled nitric oxide (iNO) in endotoxin-induced acute lung injury (ALI).¶Design: Prospective, randomised, controlled experimental study.¶Setting: A medical university hospital research laboratory.¶Intervention: Twenty-nine adult rabbits (2.4–3.4 kg) were given two doses of intravenous endotoxin(More)
Surfactant protein A (SP-A) increases the resistance of surfactant to inhibition by plasma and other proteins. In a previous study we found that a monoclonal anti-SP-A antibody (R 5) increased the sensitivity of surfactant to inhibition by fibrinogen in vivo and in vitro. SP-A has been shown to stimulate microbial phagocytosis and killing by alveolar(More)
Gastric cancer (GC) is one of the most frequently diagnosed malignancies in East Asia, particularly in China, and remains the second leading cause of cancer-associated mortality worldwide. However, no effective plasma biomarkers have been identified for the diagnosis of patients with GC. The aim of this study was to investigate the DNA methylation status of(More)
Fragestellung: Mit Hilfe eines Tiermodells der neonatalen B-Streptokokken-Pneumonie sollte der Einfluß von Surfactant auf das pulmonale Entzündungsgeschehen und die Freisetzung von Elastase, einem proteolytischen Enzym neutrophiler Granulozyten, untersucht werden. Methode: Kaninchenfeten mit einer Tragzeit von 29,5 Tagen wurden intratracheal mit(More)
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