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Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
TLDR
It is reported here that the IκB kinase (IKK)–related kinases IKKϵ and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRf-3 and IRF-7. Expand
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19. Expand
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.
TLDR
Evidence is presented that the attenuated vesicular stomatitis strains, AV1 and AV2, embody all of the traits of an oncolytic virus, which will replicate preferentially in malignant cells, have the ability to treat disseminated metastases, and ultimately be cleared by the patient. Expand
Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
TLDR
Results demonstrate that, in addition to its role in the formation of a functional immediate-early IFN-β enhanceosome, IRF-3 is able to discriminate among ISRE-containing genes involved in the establishment of the antiviral state as a direct response to virus infection. Expand
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.
TLDR
It is concluded that IKKepsilon plays a critical role in the IFN-inducible antiviral transcriptional response and directly phosphorylates signal transducer and activator of transcription 1, a component of ISGF3. Expand
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
TLDR
A quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells reveals dramatic rewiring of phosphorylation on host and viral proteins, revealing potential COVID-19 therapies. Expand
Identification of the Minimal Phosphoacceptor Site Required for in Vivo Activation of Interferon Regulatory Factor 3 in Response to Virus and Double-stranded RNA*
TLDR
It is demonstrated for the first time that, in vivo, IRF-3 is phosphorylated on Ser396 following Sendai virus infection, expression of viral nucleocapsid, and double-stranded RNA treatment. Expand
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
TLDR
It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids. Expand
Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity
TLDR
It is shown that IKKϵ plays a critical role in the IFN-inducible antiviral transcriptional response and phosphorylates signal transducer and activator of transcription 1 (STAT1), a component of ISGF3. Expand
The interferon antiviral response: from viral invasion to evasion
TLDR
The present review focuses on recent reports that describe the activation of multiple signalling pathways following virus infection, new candidate genes that are implicated in the establishment of the antiviral state, and the strategies used by viruses and their specific viral products to antagonize and evade the host antiviral response. Expand
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