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Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
- M. Herkenham, Abigail K. Lynn, M.Ross Johnson, LS Melvin, B. de Costa, KC Rice
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 February 1991
The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement. Expand
Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells
- I. Paul, A. Basile, +5 authors G. Kuijpers
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 September 1993
It is reported that σ receptor ligands noncompetitively inhibit nicotine‐stimulated catecholamine release from bovine adrenal chromaffin cells in a concentration‐dependent and reversible manner and the actions of agonists at the nicotinic acetylcholine receptor in bovines chromaff in cells are modulated by σ1 receptor selective ligands. Expand
Interaction of β‐funaltrexamine with [3H]cycloFOXY binding in rat brain: Further evidence that β‐FNA alkylates the opioid receptor complex
β‐Funaltrexamine (β‐FNA) is an alkylating derivative of naltrexone. In addition to acting as an irreversible inhibitor of μ‐receptor‐mediated physiological effects, intracerebroventricular (i.c.v.)… Expand
Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations.
- A. Basile, I. Paul, A. Mirchevich, G. Kuijpers, B. de Costa
- Chemistry, Medicine
- Molecular pharmacology
- 1 November 1992
Results indicate that physiologically relevant concentrations of divalent cations allosterically modulate (+)-[3H]pentazocine binding to the sigma 1 receptor, to reveal multiple affinity states, consistent with a potential role for sigma receptors as constituents of cation channels. Expand
Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers.
Data suggest further in vivo evidence for a functional mediation by sigma sites of the emetic response to DTG in the pigeon, and may provide in vivoevidence for potential allosteric modification of sigma ligands. Expand
Differential effects of cytochrome P-450 induction on ligand binding to sigma receptors.
The identity of the sigma receptor as a form of cytochrome P-450 was investigated in rats treated with 3-methylcholanthrene or phenobarbital. The density of [3H]N,N'-di(o-tolyl)guanidine (DTG)… Expand