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- Publications
- Influence
Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation
- B. Zurek, M. Proell, Roland N. Wagner, R. Schwarzenbacher, T. Kufer
- Biology, Medicine
- Innate immunity
- 1 February 2012
Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 are intracellular pattern recognition receptors (PRRs) of the nucleotide-binding domain and leucine-rich repeat containing… Expand
TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation
- B. Zurek, Ida Schoultz, +8 authors T. Kufer
- Biology, Medicine
- PloS one
- 19 July 2012
NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe… Expand
NOD-Like Receptor Activation by Outer Membrane Vesicles from Vibrio cholerae Non-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR
- H. Bielig, P. Rompikuntal, +5 authors T. Kufer
- Biology, Medicine
- Infection and Immunity
- 24 January 2011
ABSTRACT Vibrio cholerae is an inhabitant of aquatic systems and one of the causative agents of severe dehydrating diarrhea in humans. It has also emerged as an important cause of different kinds of… Expand
The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling
NOD1 is an intracellular pathogen recognition receptor that contributes to anti-bacterial innate immune responses, adaptive immunity and tissue homeostasis. NOD1-induced signaling relies on actin… Expand
Engagement of Nucleotide-binding Oligomerization Domain-containing Protein 1 (NOD1) by Receptor-interacting Protein 2 (RIP2) Is Insufficient for Signal Transduction*
- Sophie Mayle, Joseph P. Boyle, Eiki Sekine, B. Zurek, T. Kufer, T. Monie
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 June 2014
Background: Protein/protein interactions are critical for signal transduction. Results: Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) helix 2 mutants impair signaling but not… Expand
A function for AAMP in Nod2-mediated NF-kappaB activation.
The WD40 repeat containing angio-associated migratory cell protein (AAMP) was identified as a new binding partner of the human nucleotide-binding domain, leucine rich repeat containing (NLR) family… Expand
A role for quorum sensing in regulating innate immune responses mediated by Vibrio cholerae outer membrane vesicles (OMVs)
- H. Bielig, Mitesh Dongre, B. Zurek, S. Wai, T. Kufer
- Biology, Medicine
- Gut microbes
- 1 September 2011
Outer membrane vesicles (OMVs) are released from many Gram-negative bacteria. OMVs interact with and are taken up by human cells. We and others have now showed that OMVs contain peptidoglycan, which… Expand
Cell-based reporter assay to analyze activation of Nod1 and Nod2.
Nod1 and Nod2 are pattern recognition receptors of the mammalian innate immune system. They respond to bacterial peptidoglycan fragments and are implicated in host defense against a variety of… Expand