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- Publications
- Influence
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
- Z. Rajić, M. Z. Končić, +4 authors B. Zorc
- Chemistry, Medicine
- Acta pharmaceutica
- 1 September 2010
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity Novel primaquine conjugates with non-steroidal anti-inlammatory drugs (PQ-NSAIDs, 4a-h) were… Expand
Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
- I. Perković, I. Butula, +5 authors B. Zorc
- Medicine, Chemistry
- European Journal of Medicinal Chemistry
- 3 March 2012
Abstract
The novel 1-acyl-4-cycloalkyl/arylsemicarbazides (5a–y) and 1-acyl-5-benzyloxy/hydroxycarbamoylcarbazides (8a–f) derived from the nonsteroidal anti-inflammatory drugs ibuprofen,… Expand
Inhibition of high affinity choline uptake in the rat brain by neurotoxins: Effect of monosialoganglioside GM1
- D. Maysinger, B. Leavitt, B. Zorc, I. Butula, A. Ribeiro-da-Silva
- Biology, Medicine
- Neurochemistry International
- 1 April 1992
Mustard derivatives of ethyl-choline and hemicholinium-3 have been suggested as possible specific cholinergic neurotoxins. In this study a structural analog of hemicholinium-3,… Expand
Novel urea and bis-urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation.
- I. Perković, M. Antunović, +9 authors B. Zorc
- Chemistry, Medicine
- European journal of medicinal chemistry
- 29 November 2016
A series of novel compounds 3a-j and 6a-j with primaquine and hydroxyl or halogen substituted benzene moieties bridged by urea or bis-urea functionalities were designed, synthesized and evaluated for… Expand
Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids.
- M. Barbarić, S. Ursic, +10 authors M. Mintas
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 September 2004
In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) demonstrated that 2b,d,e exhibited rather marked inhibitory activity (IC50 = 7-10 microM) against pancreatic… Expand
Primaquine hybrids as promising antimycobacterial and antimalarial agents.
- K. Pavić, I. Perković, +8 authors B. Zorc
- Chemistry, Medicine
- European journal of medicinal chemistry
- 2018
Four series of primaquine (PQ) derivatives were screened for antitubercular and antiplasmodial activity: amides 1a-k, ureas 2a-s, semicarbazides 3a-c and bis-ureas 4a-u. Antimycobacterial activity of… Expand
Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule
- Issan Zhang, M. Beus, +5 authors D. Maysinger
- Chemistry, Medicine
- Cell Death Discovery
- 26 September 2018
Glioblastoma multiforme is one of the most aggressive brain tumors and current therapies with temozolomide or suberoylanilide hydroxamic acid (SAHA, vorinostat) show considerable limitations. SAHA is… Expand
Insights into the mechanism of antiproliferative effects of primaquine-cinnamic acid conjugates on MCF-7 cells
Abstract In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage… Expand
Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
- I. Perković, S. Raić-Malić, +7 authors Z. Rajić
- Chemistry, Medicine
- European journal of medicinal chemistry
- 29 November 2019
Harmicines constitute novel hybrid compounds that combine two agents with reported antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative (CAD). Cu(I) catalyzed… Expand
Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents
- M. Beus, Diana Fontinha, +5 authors B. Zorc
- Chemistry, Medicine
- Molecules
- 1 August 2019
This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric… Expand
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