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Primaquine hybrids as promising antimycobacterial and antimalarial agents.
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
Novel primaquine conjugates with non-steroidal anti-inlammatory drugs (PQ-NSAIDs, 4a-h) were prepared, fully chemically characterized and screened for radical scavenging and antioxidant activities.
Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
Structural and electronic determinants of flavonoid binding to human serum albumin: an extensive ligand-based study
Flavonoids are ubiquitous plant metabolites that interfere with different biological processes in the human organism. After absorption they bind to human serum albumin (HSA), the most abundant…
Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule
Glioblastoma multiforme is one of the most aggressive brain tumors and current therapies with temozolomide or suberoylanilide hydroxamic acid (SAHA, vorinostat) show considerable limitations. SAHA is…
Novel urea and bis-urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation.
Inhibition of high affinity choline uptake in the rat brain by neurotoxins: Effect of monosialoganglioside GM1
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations.
Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
Fenoprofen and Ketoprofen Amides as Potential Antitumor Agents
- M. Marjanović, B. Zorc, L. Pejnović, M. Zovko, M. Kralj
- Chemistry, BiologyChemical biology & drug design
- 1 March 2007
The growth inhibitory activity of the tested amides clearly demonstrates that the substituents linked by an amide bond are essential for the significantly stronger cytostatic activity, probably because of a greater lipophilicity and/or better cell uptake.