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Macrophage activation and its role in repair and pathology after spinal cord injury
The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but… Expand
Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
Although insulin-like growth factor 1 (IGF-1) has been associated with retinopathy, proof of a direct relationship has been lacking. Here we show that an IGF-1 receptor antagonist suppresses retinal… Expand
SWI/SNF unwraps, slides, and rewraps the nucleosome.
- Stefan R Kassabov, B. Zhang, J. Persinger, B. Bartholomew
- Biology, Medicine
- Molecular cell
- 1 February 2003
The structure of the SWI/SNF-remodeled nucleosome was characterized with single base-pair resolution by mapping the contacts of specific histone fold residues with nucleosomal DNA. We demonstrate… Expand
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.
- A. McDermott, R. Redfern, B. Zhang, Y. Pei, L. Huang, R. Proske
- Medicine, Biology
- Investigative ophthalmology & visual science
- 1 May 2003
PURPOSE To investigate the expression of human beta-defensins (hBDs) by human corneal epithelium and determine the effects of proinflammatory cytokines on expression of human beta-defensin (hBD)-2 by… Expand
Architecture of the SWI/SNF-Nucleosome Complex
- M. L. Dechassa, B. Zhang, +4 authors B. Bartholomew
- Biology, Medicine
- Molecular and Cellular Biology
- 21 July 2008
ABSTRACT The SWI/SNF complex disrupts and mobilizes chromatin in an ATP-dependent manner. SWI/SNF interactions with nucleosomes were mapped by DNA footprinting and site-directed DNA and protein… Expand
An overview of biomarkers for the ovarian cancer diagnosis.
Even though there are a lot of options in treating gynecological malignancies, ovarian cancer still remains a leading cause of death. Diagnosis at an early stage is the most important determinant of… Expand
Ethnicity modifies the association between functional microRNA polymorphisms and breast cancer risk: a HuGE meta-analysis
Common functional polymorphisms in the promoter region of microRNAs (miRNAs), based on multiple lines of evidence, might participate in transcriptional regulation and other biological processes,… Expand
Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin
- M. Riddle, R. Henry, +5 authors D. Maggs
- Diabetes/metabolism research and reviews
- 1 November 2006
In two placebo‐controlled 30‐week trials, treatment with exenatide reduced HbA1c and body weight in patients with type 2 diabetes in the context of sulphonylurea (SU) or SU plus metformin (MET) as… Expand
Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer.
- Gui-fang Guo, Wen-Qi Jiang, +5 authors L. Xia
- World journal of gastroenterology
- 21 November 2011
AIM To investigate the utility of Beclin-1 and LC3, two autophagy-related proteins, in predicting the cetuximab efficacy in advanced colorectal cancer (ACRC). METHODS The data of 85 patients with… Expand
PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib
Sorafenib is currently the only systemic agent approved for treatment of advanced hepatocellular carcinoma (HCC). However, intrinsic and acquired resistance to sorafenib remains a great challenge… Expand