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Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
Frontotemporal dementia with parkinsonism chromosome 17 type (FTDP-17) is caused by mutations in MAPT, the gene encoding tau. FTDP-17 begins with executive function deficits and other abnormalExpand
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Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B1
CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study,Expand
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The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
Alzheimer’s disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability. Genetic andExpand
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Molecular Phylogeny of Bactrocera Species (Diptera: Tephritidae: Dacini) Inferred from Mitochondrial Sequences of 16S rDNA and COI Sequences
ABSTRACT Many fruit flies in the genus Bactrocera (Diptera: Tephritidae: Dacini) are economically important insects. However, little attention has been given to the molecular phylogeneticExpand
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Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
BackgroundThe coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immuneExpand
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Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes
Interferon (IFN) signature genes have been shown to be expressed highly in peripheral blood of patients with systemic lupus erythematosus (SLE), especially in the presence of active disease. However,Expand
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Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations.
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. However, we know little of mutational spectrum in the Chinese population. Thus, here we report the identification ofExpand
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Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
Three major MAP kinase signaling cascades, ERK, p38, and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonalExpand
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Genotypic and Phenotypic Features of BAP1 Cancer Syndrome: A Report of 8 New Families and Review of Cases in the Literature
Importance Patients with germline mutations in BAP1 may develop several flesh-colored melanocytic BAP1–mutated atypical intradermal tumors (MBAITs). These tumors generally develop earlier than otherExpand
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Phenotypic characterization and anti-tumor effects of cytokine-induced killer cells derived from cord blood.
BACKGROUND AIMS Cytokine-induced killer (CIK) cell therapy represents a feasible immunotherapeutic option for treating malignancies. However, the number of anti-tumor lymphocytes cannot be easilyExpand
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