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The Norway spruce genome sequence and conifer genome evolution
TLDR
The draft assembly of the 20-gigabase genome of Norway spruce (Picea abies), the first available for any gymnosperm, is presented, revealing numerous long (>10,000 base pairs) introns, gene-like fragments, uncharacterized long non-coding RNAs and short RNAs, which opens up new genomic avenues for conifer forestry and breeding. Expand
Genetic structure and diversity of cultivated soybean (Glycine max (L.) Merr.) landraces in China
TLDR
The Chinese genebank contains 23,587 soybean landraces collected from 29 provinces and seven clusters were inferred, providing the first molecular evidence for the hypotheses that the origin of cultivated soybean is the Yellow River region. Expand
Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein
TLDR
It is reported that cyclophilins (CyPs), a family of cellular peptidyl-prolyl isomerases (PPIases), play a role in flavivirus replication, and antiviral experiments demonstrated that cyclosporine (Cs; an 11-amino-acid cyclic peptide known to block the PPIase activity of CyPA) inhibits flaviv virus replication in cell culture at nontoxic concentrations. Expand
West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism
TLDR
These results demonstrate that flavivirus methyltransferase catalyzes two cap methylations through a substrate-repositioning mechanism that is essential for viral replication and inhibitors designed to block the pocket identified for the N7 cap methylation could be developed for flaviv virus therapy. Expand
West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions.
TLDR
The 5'UAR/3' UAR pairing may release the 3' end of viral genome (as a template) during the initiation of minus-strand RNA synthesis, but not for viral translation. Expand
25‐Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
TLDR
It is demonstrated that cholesterol‐25‐hydroxylase (CH25H) was induced in response to ZikV infection and that its enzymatic product, 25‐hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. Expand
Flavivirus methyltransferase: a novel antiviral target.
TLDR
Current understanding of flavivirus RNA cap methylation and its implications for development of antivirals are reviewed and it is demonstrated that the N-7 MTase represents a novel target for flaviv virus therapy. Expand
Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2′-O Methylation
TLDR
The results demonstrate the feasibility of using 2′-O methylation-defective virus as a vaccine approach and this vaccine approach should be applicable to other flaviviruses and nonflavivirus that encode their own viral 2′/O methyltransferases. Expand
Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein.
TLDR
The study has provided further evidence to suggest that flavivirus genome cyclization and NS5/5'SL1 RNA interaction facilitate NS5 binding to the 3' end of the genome for the initiation of viral minus-strand RNA synthesis. Expand
Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events
TLDR
It is reported that nonstructural protein 5 (NS5) from four serocomplexes of flaviviruses specifically methylates the cap through recognition of the 5′ terminus of viral RNA. Expand
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