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Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci
ABSTRACT Cellular senescence is an irreversible proliferation arrest triggered by short chromosome telomeres, activated oncogenes, and cell stress and mediated by the pRB and p53 tumor suppressorExpand
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Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells.
Cellular senescence is an irreversible proliferation arrest of primary cells and an important tumor suppression process. Senescence is often characterized by domains of facultative heterochromatin,Expand
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c‐Src, Insulin‐Like Growth Factor I Receptor, G‐Protein‐Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes
It is well known that Src tyrosine kinase, insulin‐like growth factor 1 receptor (IGF‐IR), and focal adhesion kinase (FAK) play important roles in prostate cancer (PrCa) development and progression.Expand
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Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation
The ionotropic glutamate receptors (NMDAR) are composed of large complexes of multi-protein subunits creating ion channels in the cell plasma membranes that allow for influx or efflux of mono- orExpand
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The αvβ6 Integrin Is Transferred Intercellularly via Exosomes*
Background: The αvβ6 integrin is up-regulated in cancer progression and metastasis. Results: This integrin is transferred via exosomes from prostate cancer cells expressing αvβ6 into αvβ6-negativeExpand
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Premature Senescence and Increased TGFβ Signaling in the Absence of Tgif1
Transforming growth factor β (TGFβ) signaling regulates cell cycle progression in several cell types, primarily by inducing a G1 cell cycle arrest. Tgif1 is a transcriptional corepressor that limitsExpand
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Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2.
The molecular circuitries controlling osseous prostate metastasis are known to depend on the activity of multiple pathways, including integrin signaling. Here, we demonstrate that the αvβ6 integrinExpand
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Somatic mutations in MAP3K5 attenuate its pro-apoptotic function in melanoma through increased binding to Thioredoxin
Patients with advanced metastatic melanoma have poor prognosis and the genetics underlying its pathogenesis are poorly understood. High throughput sequencing has allowed comprehensive discovery ofExpand
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The αvβ6 integrin promotes an osteolytic program through upregulation of MMP2
The molecular circuitries controlling osseous prostate metastasis are known to depend on the activity of multiple pathways, including integrin signaling. Here, we demonstrate that the αvβ6 integrinExpand
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Inhibition of CtBP1 activity by Akt-mediated phosphorylation.
Pc2 (Cbx4) is a member of the chromobox family of polycomb proteins, and is a SUMO E3 ligase for the transcriptional corepressor CtBP1. Here, we show that both CtBP1 and Pc2 are phosphorylated by theExpand
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