• Publications
  • Influence
Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.
Data indicate that AEG1 plays a central role in regulating diverse aspects of HCC pathogenesis and might lead to the shutdown of key elemental characteristics of H CC and could lead to an effective therapeutic strategy for HCC. Expand
Increased RNA‐induced silencing complex (RISC) activity contributes to hepatocellular carcinoma
A novel mechanism that overexpression of AEG‐1 and SND1 leading to increased RISC activity might contribute to hepatocarcinogenesis is unraveled and targeted inhibition of S ND1 enzymatic activity might be developed as an effective therapy for HCC. Expand
Induction of matrix metalloproteinase‐9 (MMP‐9) in lipopolysaccharide‐stimulated primary astrocytes is mediated by extracellular signal‐regulated protein kinase 1/2 (Erk1/2)
The results from the present study suggest that induction of MMP‐9 by LPS in rat primary astrocytes is mediated, at least in part, by the sequential activation of PKC and Erk1/2. Expand
Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma
  • B. Yoo, L. Emdad, +10 authors D. Sarkar
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 19 April 2010
A regulatory role of LSF in cancer, particularly HCC pathogenesis, is established, and LSF is validated as a viable target for therapeutic intervention. Expand
Molecular mechanism of chemoresistance by astrocyte elevated gene-1.
This study provides the first documentation of a unique aspect of AEG-1 function, translational and posttranslational regulation of proteins, which might provide a means of more effectively using chemotherapy to treat HCC, which displays inherent chemoresistance with aggressive pathology. Expand
Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy
Investigation of the potential contribution of astrocyte elevated gene-1 (AEG-1) in gliomagenesis and the possibility of A EG-1 as a therapeutic target for malignant glioma suggest that AEG- 1 may play a crucial role in the pathogenesis of gli cancer. Expand
Identification of genes conferring resistance to 5-fluorouracil
2 previously unidentified genes, AEG-1 and LSF, contributing to chemoresistance are highlighted and might be exploited as a therapeutic strategy along with 5-FU-based combinatorial chemotherapy for HCC, a highly fatal cancer with currently very limited therapeutic options. Expand
Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes.
The present review critically evaluates what is currently known about AEG-1 and provides new perspectives relative to this intriguing molecule that may provide a rational target for intervening in the cancer phenotype. Expand
Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology.
A snapshot of the current literature along with future perspectives on AEG-1 are provided, a highly basic protein with a transmembrane domain and multiple nuclear localization signals and it is present in the cell membrane, cytoplasm, nucleus, nucleolus and endoplasmic reticulum. Expand
Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity.
The findings suggest that AEG-1 contributes to glioma-induced neurodegeneration, a hallmark of this fatal tumor, through regulation of EAAT2 expression. Expand