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miR-204 Inhibits Epithelial to Mesenchymal Transition by Targeting Slug in Intrahepatic Cholangiocarcinoma Cells
TLDR
The findings suggest that miR-204 plays negative roles in the invasive and/or metastatic potential of ICC, and that its suppressive effects are mediated by repressing Slug expression. Expand
TGF-β upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1.
UNLABELLED Transforming growth factor β (TGF-β) plays important roles in tumor metastasis by regulating miRNAs expression. miR-182 is an important molecule in the regulation of cancer progression.Expand
Sorafenib sensitizes hepatocellular carcinoma cell to cisplatin via suppression of Wnt/β-catenin signaling
TLDR
It is demonstrated that sorafenib sensitizes human HCC cell to cisplatin via suppression of Wnt/β-catenin signaling, thus offering a new target for chemotherapy of HCC. Expand
Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer
TLDR
The role and mechanism of PHLPP and Survivin in GBC cells are revealed and proposed strategies for gene therapies targeting the miR-495 / PHL PP / AKT / Survivin regulatory pathway are proposed. Expand
Long Noncoding RNA OIP5-AS1 Promotes the Progression of Liver Hepatocellular Carcinoma via Regulating the hsa-miR-26a-3p/EPHA2 Axis
TLDR
It is demonstrated that OIP5-AS1 was upregulated in LIHC tissue specimens and its overexpression was associated with the poor survival of patients with LIHC and its effects were suggested to be promoted LIHC cell proliferation and invasion via regulating the hsa-miR-26a-3p/EPHA2 axis. Expand
Desulfation of cell surface HSPG is an effective strategy for the treatment of gallbladder carcinoma.
TLDR
This study analyzed 527 clinical GBC specimens and confirmed that the HSPG sulfation level was significantly higher in GBC tissues than in gallbladder mucosa (GBM) tissues and demonstrated that a high HSPg sulfation endows GBC with high malignant biological behaviors and a poor prognosis. Expand
Long Noncoding RNA NEAT1 Upregulates Survivin and Facilitates Gallbladder Cancer Progression by Sponging microRNA-335
TLDR
Findings indicate that NEAT1 promotes survivin expression by functioning as a competitive endogenous RNA for miR-335 in GBC cells; thus, it is identified as a potential biomarker and target for GBC diagnosis and therapy. Expand
Whole-Transcriptome Sequencing Identifies Key Differentially Expressed mRNAs, miRNAs, lncRNAs, and circRNAs Associated with CHOL
TLDR
The genes involved in RNA splicing and protein degradation processes and miR-144-3p may play fundamental roles in the pathogenesis of CHOL. Expand
[Clinical value of extended radical resection for pT3 stage gallbladder cancer].
TLDR
The overall survival rate in patients with stage pT3 GBC whose lymph node positive rate<1/3 and/or hepatic parenchymal invaded cannot be improved by extendedradical resection, and extended radical resection is an independent risk factor for patient prognosis. Expand