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Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins
TLDR
A unified molecular mechanism is provided to explain findings related to xenogeneic silencing proteins, including their lack of apparent sequence specificity but preference for AT-rich sequences, and suggest that structural information contained within the DNA minor groove is deciphered by xenogeneIC silencers to distinguish genetic material that is self from nonself.
Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium Bacillus subtilis.
TLDR
The results strongly support the postulated topology of TatA(d) in which the transmembrane helix is inserted into the lipid bilayer while the amphipathic helix lies at the membrane-water interface and revealed the structural importance of several conserved residues at the hinge region, shedding new light on further elucidation of the protein transport mechanism of the Tat system.
Conserved regulatory elements in AMPK
TLDR
It is found that the α-subunit regulatory region was incorrectly built in the Xiao et al. model, and the rebuilt model suggests a universal occurrence of the AID domain in AMPKs; it is also identified a novel regulatory motif that is essential for AMPK regulation.
Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases.
TLDR
The primary function of Grx2 as a GST-like glutaredoxin is to catalyze reversible glutathionylation of proteins with GSH in cellular redox regulation including stress responses, and E. coli Grx 2 is structurally and functionally a member of this new expanding family of large glutaredoxins.
Structural insight into poplar glutaredoxin C1 with a bridging iron-sulfur cluster at the active site.
TLDR
It is proposed that the bridging [2Fe-2S] cluster is coordinated by the first cysteine at the glutaredoxin active site from each subunit of holo Grx-C1, along with two cysteines from two glutathione molecules.
Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy
TLDR
It is demonstrated that phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy, and may represent a novel target for therapeutic intervention.
Without Its N-Finger, the Main Protease of Severe Acute Respiratory Syndrome Coronavirus Can Form a Novel Dimer through Its C-Terminal Domain
TLDR
It is reported that the SARS-CoV Mpro C-terminal domain alone (residues 187 to 306; Mpro-C) is produced in Escherichia coli in both monomeric and dimeric forms, and no exchange could be observed between them at room temperature.
A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT
TLDR
Comparison of MvaT with other bacterial xenogeneic silencers provides a clear picture that nature has evolved unique solutions for different bacterial genera to distinguish foreign from self DNA.
Periplasmic Protein HdeA Exhibits Chaperone-like Activity Exclusively within Stomach pH Range by Transforming into Disordered Conformation*
TLDR
The data provided in this report strongly suggest that HdeA employs a novel strategy to modulate its chaperone activity: it possesses an ordered conformation that is unable to bind denatured substrate proteins under normal physiological conditions and transforms into a globally disordered conformed that is able to bind substrate protein under stress conditions.
Silencing of foreign DNA in bacteria.
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