• Publications
  • Influence
Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL.
Amastigotes of Trypanosoma cruzi express surface proteins that, when released into the host cell cytoplasm, are processed and presented on the surface of infected cells in the context of MHC class IExpand
  • 95
  • 8
Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria.
Candidate malaria vaccines have failed to elicit consistently protective immune responses against challenge with Plasmodium falciparum. NYVAC-Pf7, a highly attenuated vaccinia virus with 7 P.Expand
  • 226
  • 6
Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses.
CD8+ T lymphocytes play a critical role in immunity to Trypanosoma cruzi. However, the target molecules of this T cell subset have not been elucidated. In this work, we report the identification ofExpand
  • 123
  • 5
NK Cells Regulate CD8+ T Cell Effector Function in Response to an Intracellular Pathogen 1
We studied the role of NK cells in regulating human CD8+ T cell effector function against mononuclear phagocytes infected with the intracellular pathogen Mycobacterium tuberculosis. Depletion of NKExpand
  • 163
  • 5
Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against Lethal Trypanosoma cruzi Infection
ABSTRACT DNA vaccination was evaluated with the experimental murine model ofTrypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the trypomastigote surface antigen 1Expand
  • 92
  • 5
  • PDF
The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo
The ability of Mycobacterium tuberculosis to grow in macrophages is central to its pathogenicity. We found previously that the widespread 210 strain of M. tuberculosis grew more rapidly than otherExpand
  • 71
  • 5
Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses.
Experimental models of Chagas' disease, an infection caused by the intracellular protozoan Trypanosoma cruzi, have demonstrated the crucial immunoprotective role played by CD8(+) T lymphocytes. TheseExpand
  • 81
  • 4
  • PDF
The NKp46 Receptor Contributes to NK Cell Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium1
We used human tuberculosis as a model to investigate the role of NK cytotoxic mechanisms in the immune response to intracellular infection. Freshly isolated NK cells and NK cell lines from healthyExpand
  • 173
  • 3
Characterization of a Mycobacterium tuberculosis Peptide That Is Recognized by Human CD4+ and CD8+ T Cells in the Context of Multiple HLA Alleles1
The secreted Mycobacterium tuberculosis 10-kDa culture filtrate protein (CFP)10 is a potent T cell Ag that is recognized by a high percentage of persons infected with M. tuberculosis. We determinedExpand
  • 75
  • 2
HLA-A2-restricted cytotoxic T lymphocyte responses to multiple Plasmodium falciparum sporozoite surface protein 2 epitopes in sporozoite-immunized volunteers.
CD8+ CTL specific for the Plasmodium yoelii sporozoite surface protein 2 (PySSP2) protect mice against malaria. For this reason, vaccines designed to induce CTL against P. falciparum SSP2 (PfSSP2)Expand
  • 65
  • 2