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Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
The First Key Symposium was held in Stockholm, Sweden, 2–5 September 2003. The aim of the symposium was to integrate clinical and epidemiological perspectives on the topic of Mild CognitiveExpand
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Current concepts in mild cognitive impairment.
The field of aging and dementia is focusing on the characterization of the earliest stages of cognitive impairment. Recent research has identified a transitional state between the cognitive changesExpand
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The age-dependent relation of blood pressure to cognitive function and dementia
The relation of blood pressure with cognitive function and dementia has, in recent years, received much attention from epidemiological research. Some cross-sectional studies have shown an inverseExpand
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Predictors of progression from mild cognitive impairment to Alzheimer disease
Objective: To determine the occurrence of neuropsychiatric symptomatology and the relation to future development of Alzheimer disease (AD) in persons with and without mild cognitive impairment (MCI).Expand
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Influence of social network on occurrence of dementia: a community-based longitudinal study
BACKGROUND Few data are available on the effect of social ties on dementia development. This study explored whether single social network components and different degrees of the social connectionsExpand
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CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
CONTEXT Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI),Expand
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The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in mitochondria.Expand
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Mental, Physical and Social Components in Leisure Activities Equally Contribute to Decrease Dementia Risk
Background: There is accumulating evidence in the literature that leisure engagement has a beneficial effect on dementia. Most studies have grouped activities according to whether they wereExpand
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Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.
OBJECTIVES To study the diagnostic potential of the 42 amino acid form of beta-amyloid (beta-amyloid(1-42)) in cerebrospinal fluid (CSF) as a biochemical marker for Alzheimer disease (AD), theExpand
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Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.
BACKGROUND Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascularExpand
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