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Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
TLDR
The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or in combination with ionizing radiation were studied with MCF-7 human breast cancer cells and FSaII mouse fibrosarcoma cells, finding it was preferentially cytotoxic to cancer stem cells relative to non-cancer stem cells. Expand
Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response.
TLDR
It is concluded that SU6668 is a potent therapeutic agent potentially useful to suppress tumor growth and enhance the response of tumors to radiotherapy. Expand
Enhancement of tumor thermal therapy using gold nanoparticle–assisted tumor necrosis factor-α delivery
TLDR
A newly developed nanoparticle delivery system consisting of 33-nm polyethylene glycol–coated colloidal gold nanoparticles (PT-cAu-TNF-α) with incorporated T NF-α payload (several hundred TNF- α molecules per nanoparticle) is used to maximize tumor damage and minimize systemic exposure to TNF -α. Expand
Arsenic trioxide induces selective tumour vascular damage via oxidative stress and increases thermosensitivity of tumours
TLDR
The results suggest that the clinical use of ATO to increase tumour thermosensitivity via direct cellular and vascular effects appears feasible and that the expression of adhesion molecules by the vasculature due to oxidative stress contribute to the ATO-induced selective tumour vascular effects observed. Expand
Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells
TLDR
Investigation of the effect of anginex on established tumor vasculature as an adjuvant to radiation therapy of solid tumors supports the idea that the combination of the antiangiogenic agentAnginex and radiation may lead to improved clinical outcome in treating cancer patients. Expand
Response of Breast Cancer Cells and Cancer Stem Cells to Metformin and Hyperthermia Alone or Combined
TLDR
The combined effects of metformin and hyperthermia against MCF-7 and MDA-MB-231 human breast cancer cell, and MIA PaCa-2 human pancreatic cancer cells are investigated to show thathyperthermia activates AMPK and inactivates mTOR and its downstream effector S6K and for the first time, it is concluded that the effects of meetformin against cancer cells including CSCs can be markedly enhanced byHyperthermia. Expand
Antiangiogenesis therapy using a novel angiogenesis inhibitor, anginex, following radiation causes tumor growth delay
TLDR
Results suggest that a combination of anginex and radiation can greatly affect the amount of functional vasculature in tumors and prolong radiation-induced tumor regression, and will be useful by blocking angiogenesis-dependent regrowth of vessels. Expand
Use of a Fluorescently Labeled Poly-Caspase Inhibitor for in Vivo Detection of Apoptosis Related to Vascular-Targeting Agent Arsenic Trioxide for Cancer Therapy
TLDR
Apoptosis appears to be a major mode of cell death induced by ATO in the tumor and the use of fluorescently tagged caspase inhibitors to assess cell death in live animals appears feasible to monitor and/or confirm anti-tumor effects of therapy. Expand
Synergistic Effects of Radiation and β-Lapachone in DU-145 Human Prostate Cancer Cells In Vitro
TLDR
The results lead to conclude that the synergistic interaction between β-lap and radiation in killing cells is the result of two distinct mechanisms: First, radiation sensitizes cells to β- Lapachone by up-regulating NQO1, and second,β-lap sensitized cells to radiation by inhibiting SLD repair. Expand
Heat-Induced Up-Regulation of NAD(P)H:Quinone Oxidoreductase Potentiates Anticancer Effects of β-Lapachone
TLDR
The heat-induced up-regulation of NQO1 enhanced the anticancer effects of β-lapachone in vitro and in vivo, and was observed for the first time that mild heat shock up-regulates N QO1 in tumor cells. Expand
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