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A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.
In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of enhancer of zeste homolog 2 (Ezh2). Tumor cells show little residualExpand
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Complex controls: the role of alternative promoters in mammalian genomes.
Despite the wealth of sequence data available from human, mouse and other genomes, our understanding of the mechanisms involved in regulating transcription and creating protein diversity isExpand
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Evolution of NK receptors: a single Ly49 and multiple KIR genes in the cow
Natural killer (NK) cell receptors for classical MHC class I molecules are encoded by the killer Ig‐like receptor (KIR) multigene family in humans and other primates. Mouse NK cells, however, employExpand
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The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we identified to our knowledge the first unifying genetic network common to the two subgroups of KMT2AExpand
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Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice.
Ly49-mediated recognition of MHC-I molecules on host cells is considered vital for natural killer (NK)-cell regulation and education; however, gene-deficient animal models are lacking because of theExpand
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The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexesExpand
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Ly49 and CD94/NKG2: developmentally regulated expression and evolution
Summary: Murine natural killer (NK) cells express two families of MHC class I‐specific receptors, namely the Ly49 family and CD94/NKG2 heterodimers. Stochastic co‐expression of these receptorsExpand
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The Schizosaccharomyces pombe JmjC-Protein, Msc1, Prevents H2A.Z Localization in Centromeric and Subtelomeric Chromatin Domains
Eukaryotic genomes are repetitively packaged into chromatin by nucleosomes, however they are regulated by the differences between nucleosomes, which establish various chromatin states. LocalExpand
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Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells
The regulation of posttranscriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development, and immunity. The receptor tyrosine phosphatase CD45, which isExpand
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Comparative analysis of the promoter regions and transcriptional start sites of mouse Ly49 genes
Abstract. Despite numerous studies on the function of Ly49 natural killer cell receptors in the mouse, relatively little is known about how these genes are regulated at the transcriptional level. InExpand
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