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Randomized, Controlled Clinical Trial of Zonisamide as Adjunctive Treatment for Refractory Partial Seizures
TLDR
This study was designed to evaluate efficacy and safety of zonisamide (ZNS) as adjunctive treatment for patients with refractory partial seizures. Expand
Acute Pancreatitis Coincident with Valproate Use: A Critical Review
TLDR
Cases of pancreatitis in VPA‐treated patients from the clinical database of VPA/divalproex trials are reviewed and the incidence of elevated amylase levels between VPA- and placebo-treated patients are compared. Expand
Rapid gas-liquid chromatographic determination of carbamazepine in plasma.
TLDR
A rapid, sensitive method is described for the quantitative determination of carbamazepine in plasma and the derivatives formed by the reaction of the drug and internal standard with dimethylformamide dimethyl acetal are stable for at least 17 h. Expand
Pharmacokinetics and safety of a phenytoin prodrug given IV or IM in patients
TLDR
The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively, and peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration. Expand
Selenium, zinc, and copper changes with valproic acid
TLDR
Patients who were treated chronically, with VPA as the sole anticonvulsant medication, had decreased plasma selenium levels, which could be due to decreased seenium concentrations when mechanisms for protection against peroxidative damage are not fully developed. Expand
Plasma kinetics of diphenylhydantoin in dogs and cats.
Extended-release formulations: simplifying strategies in the management of antiepileptic drug therapy
TLDR
The dosing flexibility and consistency of serum levels (without marked peak-to-trough fluctuations) conferred by extended-release formulations help achieve the primary treatment goals for many patients with epilepsy: preventing occurrence of seizures and preventing or reducing side effects. Expand
Methsuximide for refractory complex partial seizures
TLDR
Methsuximide appeared to be an effective and generally well tolerated adjunct medication in the management of complex partial seizures. Expand
Abnormalities of antioxidant metabolism in a case of Friedreich's disease.
TLDR
A patient with Friedreich's disease who exhibited abnormalities of antioxidant metabolism, including decreased levels of glutathione peroxidase, glutathion reductase, and selenium, and an increased lipid peroxide index, became normal after treatment with N-acetylcysteine, selenia, and low-dose vitamin E therapy. Expand
Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.
TLDR
The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively, and peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration. Expand
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