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Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule
- G. Ramage, S. Saville, B. Wickes, J. Lopez-Ribot
- BiologyApplied and Environmental Microbiology
- 1 November 2002
The results indicate that farnesol acts as a naturally occurring quorum-sensing molecule which inhibits biofilm formation, and its potential for further development and use as a novel therapeutic agent is discussed.
The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans.
Results suggest that hyphal formation is pivotal for biofilm development in C. albicans, however, the sessile lifestyle associated with adherent cells confers antifungal resistance, regardless of coherent biofilm formation.
Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms.
- G. Ramage, S. Bachmann, T. Patterson, B. Wickes, J. Lopez-Ribot
- BiologyThe Journal of antimicrobial chemotherapy
- 1 June 2002
It was demonstrated that expression of genes encoding both types of efflux pump were up-regulated during the course of biofilm formation and development, and antifungal susceptibilities of biofilms formed by a set of C. albicans mutant strains deficient in efflux pumps were investigated to determine their contribution to biofilm resistance.
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans
Comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes, and the genome is rich in transposons, many of which cluster at candidate centromeric regions.
Genomic Analysis of the Basal Lineage Fungus Rhizopus oryzae Reveals a Whole-Genome Duplication
The order and genomic arrangement of the duplicated gene pairs and their common phylogenetic origin provide evidence for an ancestral whole-genome duplication (WGD) event that resulted in the expansion of multiple gene families related to cell growth and signal transduction, as well as secreted aspartic protease and subtilase protein families, which are known fungal virulence factors.
Standardized Method for In Vitro Antifungal Susceptibility Testing of Candida albicansBiofilms
- G. Ramage, Kacy Vande Walle, B. Wickes, J. Lopez-Ribot
- BiologyAntimicrobial Agents and Chemotherapy
- 1 September 2001
A rapid and highly reproducible microtiter-based colorimetric assay for the susceptibility testing of fungal biofilms, based on the measurement of metabolic activities of the sessile cells by using a formazan salt reduction assay, which represents a promising tool for the standardization of in vitro antifungal susceptibility testing.
Genetic association of mating types and virulence in Cryptococcus neoformans
Testing for virulence in mice suggested the genetic association of virulence with mating type in this human fungal pathogen alpha type was clearly more virulent than a type.
Characteristics of biofilm formation by Candida albicans.
- G. Ramage, K. VandeWalle, B. Wickes, J. Lopez-Ribot
- BiologyRevista iberoamericana de micologia
- 1 December 2001
Mature C. albicans biofilms displayed a complex three dimensional structure which demonstrated spatial heterogeneity and a typical architecture showing microcolonies with ramifying water channels, and the XTT-reduction assay showed a linear relationship between cellular density of the biofilm and metabolic activity.
Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type.
- B. Wickes, M. Mayorga, U. Edman, J. Edman
- BiologyProceedings of the National Academy of Sciences…
- 9 July 1996
It is shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions and the association of the hyphalphase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. Neoformans.
Fungal Planet description sheets: 214–280
Novel species of microfungi described in the present study include the following from South Africa: Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus…