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Studies of early hepatocellular proliferation and peroxisomal proliferation in Wistar rats treated with herbicide diclofop.
TLDR
The results presented here demonstrate clearly that diclofop belongs to a class of rodent PPs. Expand
[The effect of permethrin and DDT on the activity of cytochrome P-450 1A and 2B molecular forms in rat liver].
TLDR
The present results indicate that permethrin as well as DDT shows the ability to induce the phenobarbital-type of cytochrome P-4502B. Expand
[Comparative study of the effect of synthetic pyrethroids on the induction of genetic changes in mice somatic and sex cells depending on the exposure route].
TLDR
The results showed the difference in the action of the pyrethroids on the genetic material of the tested cells and the effect of the route of exposure, however a substantial increase in the micronuclei frequency in the bone marrow was observed after oral exposure only. Expand
Di-butyl phthalate—induced hypomethylation of the c-myc gene in rat liver
TLDR
It is hypothesized that DBP-induced demethylation of the c-myc gene was an active mechanism, not associated with DNMTs activity and DNA replication, as well as being close to the dose that increases the numbers of peroxisomes in male Wistar rats. Expand
Influence of chlorpyrifos on the profile of subpopulations of immunoactive cells and their phagocytic activity in an experimental in vivo model.
TLDR
The present study attempts to define the influence of chlorpyrifos on the profile of subpopulations of immunoactive cells: B, T, CD4+, CD8+, and NK, and on their phagocytic activity in an experimental in vivo model, and fails to demonstrate a statistically significant decrease in the phagocytetic activity of the granulocyte. Expand
Effect of chlorpyrifos on the profile of subpopulations immunocompetent cells B, T and NK in in vivo model.
TLDR
The study demonstrated changes in white-blood cell (lymphocyte) response profiles, reflecting an immunomodulation although such changes were equivocal, where both suppression and stimulation were observed. Expand
[Phenobarbital-induced hypermethylation of the p53 promoter region in the liver of Wistar rats].
TLDR
It is proposed that PB-induced de novo methylation of the p53 gene was not associated with DNMTs activity, and this mechanism of their toxicity, including carcinogenic action was not proposed. Expand
Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop.
TLDR
It is concluded that fluazifop produces in male Wistar rats hepatomegaly due to cellular hypertrophy and can be classified as a weak rodent PPs. Expand
Alternative toxicological methods for establishing residue definitions applied for dietary risk assessment of pesticides in the European Union.
TLDR
Quantitative Structure-Activity Relationship (QSAR) and Threshold of Toxicological Concern (TTC) can be used for this purpose in procedure of establishing residue definitions applied for dietary risk assessment. Expand
[Induction of micronuclei in erythrocytes of bone marrow and peripheral blood in laboratory mice following acute and subchronic exposure to DDT(fenarimol and nuarimol)].
TLDR
The results show that fenarimol and nuariml did not cause micronuclei induction in the bone marrow and peripheral blood of mice under the conditions of these experiments, however, mitomycin C, cyclophosphamide and colchicine induced of micron nuclei in the investigated tissues. Expand
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