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SNAREpins: Minimal Machinery for Membrane Fusion
Recombinant v- and t-SNARE proteins reconstituted into separate lipid bilayer vesicles assemble into SNAREpins-SNARE complexes linking two membranes. This leads to spontaneous fusion of the dockedExpand
Mitochondrial fusion and fission in cell life and death
  • B. Westermann
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 December 2010
The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic studies have revealed the first secrets of the complex processes that govern fusion andfission of a double membrane-bound organelle. Expand
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
The cleavage by OMA1 causes an accumulation of the short OPA1 variants, and the role ofm-AAA proteases in ensuring a balance of long and short Opa1 isoforms is investigated. Expand
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.
Conditional gene targeting of murine Phb2 is used to define cellular activities of prohibitins and assign an essential function for the formation of mitochondrial cristae to prohibitingins and suggest a coupling of cell proliferation to mitochondrial morphogenesis. Expand
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria
Statement MITO-MAP, a high-density genetic interaction map in budding yeast, identifies a mitochondrial inner membrane–associated complex that promotes normal mitochondrial membrane organization andExpand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.
A systematic screen of a deletion mutant library covering the nonessential genes of Saccharomyces cerevisiae revealed unprecedented mitochondrial phenotypes that have never been observed by conventional screens, providing a comprehensive picture of the cellular processes and molecular components required for mitochondrial function and structure in a simple eukaryotic cell. Expand
The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria
Lipid profiling by mass spectrometry of GEP-deficient mitochondria reveals a critical role of cardiolipin and phosphatidylethanolamine for survival of prohibitin- deficient cells and proposes that prohibitins control inner membrane organization and integrity by acting as protein and lipid scaffolds. Expand
Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
The existence of a specific mitochondrial pyruvate carrier (MPC) has been anticipated, but its molecular identity remained unknown and it is reported that MPC is a heterocomplex formed by two members of a family of previously uncharacterized membrane proteins that are conserved from yeast to mammals. Expand
Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae*
Fzo1p is a novel component required for the biogenesis of functional mitochondria in the yeast Saccharomyces cerevisiae and presumably is the first identified component of the yeast mitochondrial fusion machinery. Expand