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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes. However,Expand
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Epigenetic memory in induced pluripotent stem cells
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through differentExpand
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Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
Higher eukaryotes must adapt a totipotent genome to specialized cell types with stable but limited functions. One potential mechanism for lineage restriction is changes in chromatin, andExpand
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Genetic evidence supports demic diffusion of Han culture
The spread of culture and language in human populations is explained by two alternative models: the demic diffusion model, which involves mass movement of people; and the cultural diffusion model,Expand
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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantialExpand
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Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.
The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an EastExpand
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Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans.
An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European menExpand
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Paternal genetic affinity between western Austronesians and Daic populations
  • H. Li, B. Wen, +16 authors L. Jin
  • Biology, Medicine
  • BMC Evolutionary Biology
  • 15 May 2008
BackgroundAustronesian is a linguistic family spread in most areas of the Southeast Asia, the Pacific Ocean, and the Indian Ocean. Based on their linguistic similarity, this linguistic familyExpand
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Genetic structure of Hmong-Mien speaking populations in East Asia as revealed by mtDNA lineages.
  • B. Wen, H. Li, +15 authors L. Jin
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 March 2005
Hmong-Mien (H-M) is a major language family in East Asia, and its speakers distribute primarily in southern China and Southeast Asia. To date, genetic studies on H-M speaking populations areExpand
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Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on theirExpand
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