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- Influence
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
- R. Irizarry, C. Ladd-Acosta, +11 authors A. P. Feinberg
- Biology, Medicine
- Nature Genetics
- 1 February 2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes. However,… Expand
Epigenetic memory in induced pluripotent stem cells
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different… Expand
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
- B. Wen, Hao Wu, Yoichi Shinkai, R. Irizarry, A. P. Feinberg
- Biology, Medicine
- Nature Genetics
- 18 January 2009
Higher eukaryotes must adapt a totipotent genome to specialized cell types with stable but limited functions. One potential mechanism for lineage restriction is changes in chromatin, and… Expand
Genetic evidence supports demic diffusion of Han culture
The spread of culture and language in human populations is explained by two alternative models: the demic diffusion model, which involves mass movement of people; and the cultural diffusion model,… Expand
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
- A. Doi, I. Park, +11 authors A. P. Feinberg
- Biology, Medicine
- Nature Genetics
- 1 December 2009
Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial… Expand
Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.
- H. Shi, Yong-li Dong, +6 authors B. Su
- Biology, Medicine
- American journal of human genetics
- 1 September 2005
The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East… Expand
Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans.
- B. Wen, Xuanhua P. Xie, +10 authors L. Jin
- Biology, Medicine
- American journal of human genetics
- 1 May 2004
An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European men… Expand
Paternal genetic affinity between western Austronesians and Daic populations
BackgroundAustronesian is a linguistic family spread in most areas of the Southeast Asia, the Pacific Ocean, and the Indian Ocean. Based on their linguistic similarity, this linguistic family… Expand
Genetic structure of Hmong-Mien speaking populations in East Asia as revealed by mtDNA lineages.
Hmong-Mien (H-M) is a major language family in East Asia, and its speakers distribute primarily in southern China and Southeast Asia. To date, genetic studies on H-M speaking populations are… Expand
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
- D. Borkin, Shihan He, +20 authors J. Grembecka
- Biology, Medicine
- Cancer cell
- 13 April 2015
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their… Expand