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Y(1)-mediated effect of neuropeptide Y in cancer: breast carcinomas as targets.
Overexpression of selected peptide receptors in human tumors has been shown to represent clinically relevant targets for cancer diagnosis and therapy. Neuropeptide Y (NPY) is a peptide… Expand
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin.
- J. Reubi, U. Läderach, B. Waser, J. O. Gebbers, P. Robberecht, J. Laissue
- Biology, Medicine
- Cancer research
- 1 June 2000
The evaluation of peptide receptors in man is needed not only to discover the physiological target tissues of a given peptide but also to identify diseases with a sufficient receptor overexpression… Expand
Neurotensin receptors: a new marker for human ductal pancreatic adenocarcinoma
Background/Aims—New imaging possibilities for early diagnosis of the devastating exocrine pancreatic adenocarcinomas would be highly welcome. Recently, pancreatic neuroendocrine tumours have been… Expand
Highly Efficient In Vivo Agonist-Induced Internalization of sst2 Receptors in Somatostatin Target Tissues
The successful peptide receptor imaging of tumors, as exemplified for somatostatin receptors, is based on the overexpression of peptide receptors in selected tumors and the high-affinity binding to… Expand
Receptor autoradiographic evaluation of cholecystokinin, neurotensin, somatostatin and vasoactive intestinal peptide receptors in gastro‐intestinal adenocarcinoma samples: Where are they really…
Receptors for cholecystokinin (CCK), gastrin, neurotensin, somatostatin and vasoactive intestinal peptide (VIP) are over‐expressed in several human tumors, where they have diagnostic and therapeutic… Expand
Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach.
BACKGROUND & AIMS Gastrin and cholecystokinin (CCK) are gut-brain peptides, with multiple functions in the gastrointestinal tract mediated through CCK-B-gastrin and CCK-A receptors. The receptor… Expand
Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice.
- A. Schmassmann, G. Zoidl, +4 authors J. Reubi
- American journal of physiology. Gastrointestinal…
- 1 April 2006
Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or… Expand
Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2.
Somatostatin receptor scintigraphy (SRS) is positive in approximately 75% of all patients with neuroendocrine gastroenteropancreatic tumours. This study aimed to identify specific somatostatin… Expand
Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue.
- J. Reubi, U. Horisberger, B. Waser, J. Gebbers, J. Laissue
- Biology, Medicine
- 1 October 1992
Somatostatin receptors were evaluated in four human gut-associated lymphoid tissues (palatine tonsils, ileal Peyer patches, vermiform appendix, and colonic solitary lymphatic follicles) using… Expand
Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors.
Histamine-secreting enterochromaffin-like (ECL) cells of the gastric fundus of the Mastomys can develop into solid ECL cell tumors, either spontaneously or after induction by acid inhibition. We used… Expand