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Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase*
Activation of the Ras/Raf/mitogen-activated protein kinase kinase/mitogen-activated protein (MAP) kinase signaling cascade is initiated by activation of growth factor receptors and regulates manyExpand
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Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein (*)
We have previously demonstrated that epidermal growth factor induced a rapid, transient decrease in gap junctional communication and increase in serine phosphorylation on the connexin-43 gap junctionExpand
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Akt Phosphorylates Connexin43 on Ser373, a “Mode-1” Binding Site for 14-3-3
Connexin43 (Cx43) is a membrane-spanning protein that forms channels that bridge the gap between adjacent cells and this allows for the intercellular exchange of information. Cx43 is regulated byExpand
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v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication
The mechanism by which v-Src disrupts connexin (Cx)43 intercellular gap junctional communication (GJC) is not clear. In this study, we determined that Tyr247 (Y247) and the previously identifiedExpand
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Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase.
The gap junction protein connexin43 is a phosphoprotein that typically migrates as three bands (nonphosphorylated, P1 and P2) during polyacrylamide gel electrophoresis. The electrophoretic mobilityExpand
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Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication.
Connexin (Cx)43 gap junction channels are phosphorylated by numerous protein kinases, with the net effect typically being a reduction in gap junction communication (GJC). This reduction must resultExpand
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Regulation of gap junctions by tyrosine protein kinases.
Most of the gap junction proteins are regulated in part by post-translational phosphorylation. Phosphorylation has been shown to be important in gap junction assembly and turnover, and for channelExpand
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Molecular dynamics and in vitro analysis of Connexin43: A new 14‐3‐3 mode‐1 interacting protein
The interaction of cellular proteins with the gap junction protein Connexin43 (Cx43) is thought to form a dynamic scaffolding complex that functions as a platform for the assembly of signaling,Expand
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Regulation of connexin43 function by activated tyrosine protein kinases
Gap junctions are specialized membrane structures that are involved in the normal functioning of numerous mammalian tissues and implicated in several human disease processes. This mini-review focusesExpand
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v-Src Tyrosine Phosphorylation of Connexin43: Regulation of Gap Junction Communication and Effects on Cell Transformation
The oncogenic tyrosine kinase, v-Src, phosphorylates connexin43 (Cx43) on Y247 and Y265 and inhibits Cx43 gap junctional communication (GJC), the process of intercellular exchange of ions andExpand
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