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Foxp1 is an essential transcriptional regulator of B cell development
Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a… Expand
Resolvin D1 protects mice from LPS-induced acute lung injury.
- B. Wang, X. Gong, +4 authors S. Min
- Chemistry, Medicine
- Pulmonary pharmacology & therapeutics
- 1 August 2011
Resolvin D1 (RvD1), an endogenous lipid molecule derived from docosahexaenoic acid (DHA), has been described to promote inflammatory resolution. The present study aimed to determine the protective… Expand
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
More than 90% of clear cell renal cell carcinomas (ccRCC) exhibit inactivation of the von Hippel-Lindau (pVHL) tumor suppressor, establishing it as the major underlying cause of this malignancy. pVHL… Expand
Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro.
BACKGROUND Stem cells, which have the ability to differentiate into insulin-producing cells (IPCs), would provide a potentially unlimited source of islet cells for transplantation and alleviate the… Expand
Targeting VEGF‐encapsulated immunoliposomes to MI heart improves vascularity and cardiac function
- R. C. Scott, Jenna M. Rosano, +5 authors M. Kiani
- Medicine, Biology
- FASEB journal : official publication of the…
- 1 October 2009
Recent attempts at rebuilding the myocardium using stem cells have yielded disappointing results. The lack of a supporting vasculature may, in part, explain these disappointing findings. However,… Expand
Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer.
Breast cancer is the second leading cause of cancer death in women, affecting 1.7 million patients every year worldwide. As a result of its heterogeneous nature, the genetic profile and associated… Expand
Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation
- Rong Yu, Z. Zhang, B. Wang, H. Jiang, L. Cheng, Li-ming Shen
- Cancer Cell International
- 11 June 2014
BackgroundHepatocellular carcinoma (HCC), the primary liver cancer, is one of the most malignant human tumors with extremely poor prognosis. The aim of this study was to investigate the anti-cancer… Expand
Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma.
BACKGROUND The aim of this study was to investigate the association of insulin-like growth factor-1 receptor (IGF-1R) with metastasis and prognosis of osteosarcoma patients. METHODS RT-PCR and… Expand
Disrupted brain anatomical connectivity in medication-naïve patients with first-episode schizophrenia
- R. Zhang, Qinling Wei, +10 authors Ruiwang Huang
- Medicine, Psychology
- Brain Structure and Function
- 1 March 2015
Previous studies suggested that the topological properties of brain anatomical networks may be aberrant in schizophrenia (SCZ), and most of them focused on the chronic and antipsychotic-medicated SCZ… Expand
miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition
Nuclear factor-κB (NF-κB) is a core regulator in multiple tumorigenic pathways. Its activation is mediated by IκB kinase β (IKKβ). Protein phosphatase PPM1B is reported to dephosphorylate IKKβ,… Expand