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A detailed examination of boronic acid–diol complexation
Inhibitors and antagonists of bacterial quorum sensing
This review has summarized recent developments inhibitors and antagonists of bacterial quorum sensing.
The relationship among pKa, pH, and binding constants in the interactions between boronic acids and diols—it is not as simple as it appears
Strategies to target the Hedgehog signaling pathway for cancer therapy
- Minhang Xin, Xinyue Ji, L. K. C. De La Cruz, Suresh Thareja, B. Wang
- Biology, ChemistryMedicinal research reviews
- 1 May 2018
Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation of the Hh signaling pathway through…
A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood.
There is an urgent need for the development of new methods for the efficient detection of sulfide in biological systems because current methods do not allow for fast, accurate, and real-time determinations of this important molecule.
Boronic acid compounds as potential pharmaceutical agents
This study reviews the recent development in boronic acid compounds during the last six years and outlines the priorities for further research into these compounds.
Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.
- S. Burroughs, Š. Kaluz, Danzhu Wang, Ke Wang, Erwin G. Van Meir, B. Wang
- BiologyFuture Medicinal Chemistry
- 1 April 2013
The HIF complex acts as a transcription factor for many genes that increase tumor survival and proliferation, and indirectly affects HIF but there have been no clinically approved direct HIF inhibitors.
Discovery and mechanistic study of a class of protein arginine methylation inhibitors.
- You Feng, Mingyong Li, B. Wang, Y. Zheng
- Biology, ChemistryJournal of medicinal chemistry
- 28 July 2010
It is revealed that this type of naphthyl-sulfo (NS) molecule directly targets the substrates but not PRMTs for the observed inhibition, which provides a new way for chemical regulation of protein arginine methylation.
Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor
- Jing Zhao, Yuhong Du, H. Fu
- Biology, ChemistryProceedings of the National Academy of Sciences
- 9 September 2011
It is suggested that FOBISIN101-like molecules could be developed as an entirely unique class of 14-3-3 inhibitors, which may serve as radiation-triggered therapeutic agents for the treatment of14-3,3-mediated diseases, such as cancer.