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A detailed examination of boronic acid–diol complexation
Abstract Boronic acids bind with compounds containing diol moieties with high affinity through reversible boronate formation. However, the conditions that foster tight binding between the diol andExpand
The relationship among pKa, pH, and binding constants in the interactions between boronic acids and diols—it is not as simple as it appears
In our continuing efforts into designing boronic acid-based sensors that recognize cell-surface carbohydrates, it has been necessary to examine various factors that affect the binding affinityExpand
Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide.
TLDR
H2S plays a major role in the protective effect of DATS against apoptosis of cardiomyocytes, and DATS-derived H2S provides effective cardioprotection. Expand
A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood.
TLDR
There is an urgent need for the development of new methods for the efficient detection of sulfide in biological systems because current methods do not allow for fast, accurate, and real-time determinations of this important molecule. Expand
Discovery and mechanistic study of a class of protein arginine methylation inhibitors.
TLDR
It is revealed that this type of naphthyl-sulfo (NS) molecule directly targets the substrates but not PRMTs for the observed inhibition, which provides a new way for chemical regulation of protein arginine methylation. Expand
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor
  • J. Zhao, Yuhong Du, +12 authors H. Fu
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 9 September 2011
TLDR
It is suggested that FOBISIN101-like molecules could be developed as an entirely unique class of 14-3-3 inhibitors, which may serve as radiation-triggered therapeutic agents for the treatment of14-3,3-mediated diseases, such as cancer. Expand
Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.
TLDR
The HIF complex acts as a transcription factor for many genes that increase tumor survival and proliferation, and indirectly affects HIF but there have been no clinically approved direct HIF inhibitors. Expand
Inhibitors and antagonists of bacterial quorum sensing
TLDR
This review has summarized recent developments inhibitors and antagonists of bacterial quorum sensing. Expand
Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.
TLDR
The first general method for the selection of boronic acid-based aptamers (boronolectins) that allows for glycan substructure focusing is described and should also be applicable to the development of aptamer for other glycoproducts, such as glycolipids and glycopeptides. Expand
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