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Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
Coordinated navigation within tissues is essential for cells of the innate immune system to reach the sites of inflammatory processes, but the signals involved are incompletely understood. Here we… Expand
L-selectin activates the Ras pathway via the tyrosine kinase p56lck.
- B. Brenner, E. Gulbins, +7 authors F. Lang
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 24 December 1996
Selectins mediate rolling, the initial step of leukocyte adhesion to endothelial cells [Springer, T. A. (1995) Annu. Rev. Physiol. 57, 827-872 and Butcher, E. C. (1991) Cell 67, 1033-1036]. In this… Expand
Bcl-Xl- and Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3.
In this study, a mechanism is reported which determines the lifetime of polymorphonuclear neutrophils (PMN). In human PMN freshly isolated from the circulation, expression of bcl-Xl, bax-alpha, and… Expand
A role for β2 integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response
- B. Walzog, P. Weinmann, F. Jeblonski, K. Scharffetter-Kochanek, K. Bommert, P. Gaehtgens
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 October 1999
Growing evidence supports the idea that adhesion via β2 integrins not only allows cellular targeting, but also induces intracellular signaling, which in turn activates functional responses of… Expand
Wound‐healing defect of CD18−/− mice due to a decrease in TGF‐β1 and myofibroblast differentiation
- Thorsten Peters, A. Sindrilaru, +14 authors K. Scharffetter-Kochanek
- Medicine, Biology
- The EMBO journal
- 5 October 2005
We studied the mechanisms underlying the severely impaired wound healing associated with human leukocyte‐adhesion deficiency syndrome‐1 (LAD1) using a murine disease model. In CD18−/− mice, healing… Expand
Midkine in Inflammation
The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role… Expand
RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo.
The receptor for advanced glycation end products (RAGE) contributes to the inflammatory response in many acute and chronic diseases. In this context, RAGE has been identified as a ligand for the… Expand
Type I iodothyronine deiodinase activity after high selenium intake, and relations between selenium and iodine metabolism in rats.
- D. Behne, A. Kyriakopoulos, H. Gessner, B. Walzog, H. Meinhold
- Chemistry, Medicine
- The Journal of nutrition
- 1 July 1992
Type I iodothyronine deiodinase (I-D), which catalyzes the production of the thyroid hormone 3,3',5-triiodothyronine from thyroxine, has recently been identified as a selenoenzyme. It is therefore of… Expand
Intracellular signalling during neutrophil recruitment
Recruitment of leucocytes such as neutrophils to the extravascular space is a critical step of the inflammation process and plays a major role in the development of various diseases including several… Expand
Intraluminal crawling versus interstitial neutrophil migration during inflammation.
Site-directed trafficking of polymorphonuclear neutrophils (PMN) to their target regions within the tissue is an important prerequisite for efficient host defense during the acute inflammatory… Expand