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Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
Coordinated navigation within tissues is essential for cells of the innate immune system to reach the sites of inflammatory processes, but the signals involved are incompletely understood. Here weExpand
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L-selectin activates the Ras pathway via the tyrosine kinase p56lck.
Selectins mediate rolling, the initial step of leukocyte adhesion to endothelial cells [Springer, T. A. (1995) Annu. Rev. Physiol. 57, 827-872 and Butcher, E. C. (1991) Cell 67, 1033-1036]. In thisExpand
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Bcl-Xl- and Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3.
In this study, a mechanism is reported which determines the lifetime of polymorphonuclear neutrophils (PMN). In human PMN freshly isolated from the circulation, expression of bcl-Xl, bax-alpha, andExpand
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A role for β2 integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response
Growing evidence supports the idea that adhesion via β2 integrins not only allows cellular targeting, but also induces intracellular signaling, which in turn activates functional responses ofExpand
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Wound‐healing defect of CD18−/− mice due to a decrease in TGF‐β1 and myofibroblast differentiation
We studied the mechanisms underlying the severely impaired wound healing associated with human leukocyte‐adhesion deficiency syndrome‐1 (LAD1) using a murine disease model. In CD18−/− mice, healingExpand
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Midkine in Inflammation
The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new roleExpand
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RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo.
The receptor for advanced glycation end products (RAGE) contributes to the inflammatory response in many acute and chronic diseases. In this context, RAGE has been identified as a ligand for theExpand
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Type I iodothyronine deiodinase activity after high selenium intake, and relations between selenium and iodine metabolism in rats.
Type I iodothyronine deiodinase (I-D), which catalyzes the production of the thyroid hormone 3,3',5-triiodothyronine from thyroxine, has recently been identified as a selenoenzyme. It is therefore ofExpand
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Intracellular signalling during neutrophil recruitment
Recruitment of leucocytes such as neutrophils to the extravascular space is a critical step of the inflammation process and plays a major role in the development of various diseases including severalExpand
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Intraluminal crawling versus interstitial neutrophil migration during inflammation.
Site-directed trafficking of polymorphonuclear neutrophils (PMN) to their target regions within the tissue is an important prerequisite for efficient host defense during the acute inflammatoryExpand
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