Discovery and resupply of pharmacologically active plant-derived natural products: A review
- A. Atanasov, B. Waltenberger, H. Stuppner
- BiologyBiotechnology Advances
- 15 August 2015
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
- Limei Wang, B. Waltenberger, A. Atanasov
- ArtBiochemical Pharmacology
- 1 November 2014
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
- H. Pein, Alexia Ville, A. Koeberle
- Biology, ChemistryNature Communications
- 20 September 2018
It is shown that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses.
Plant extracts and natural compounds used against UVB-induced photoaging
- M. Cavinato, B. Waltenberger, G. Baraldo, C. Grade, H. Stuppner, P. Jansen-Dürr
- BiologyBiogerontology (Dordrecht)
- 12 July 2017
This review summarized the most current and relevant information concerning plant extracts and natural compounds that are able to protect or mitigate the deleterious effects caused by photoaging in different experimental models.
Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin
The results indicated that prolonged TNFα exposure could have detrimental consequences to endothelial cells by causing senescence and, therefore, chronically increased TNF α levels might possibly contribute to the pathology of chronic inflammatory diseases by driving premature endothelialsenescence.
Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders.
- B. Waltenberger, A. Mocan, K. Šmejkal, E. Heiss, A. Atanasov
- BiologyMolecules
- 2016
The present review aims to serve as an "opening" of this special issue of Molecules, presenting key historical developments, recent advances, and future perspectives outlining the potential of natural products for prevention or therapy of cardiovascular and metabolic disease.
Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo
- N. Fakhrudin, B. Waltenberger, V. Dirsch
- Biology, ChemistryBritish Journal of Pharmacology
- 18 March 2014
The characterization of the natural product plumericin as a highly potent inhibitor of the NF‐κB pathway with a novel chemical scaffold, which was isolated from extracts of Himatanthus sucuuba, an Amazonian plant traditionally used to treat inflammation‐related disorders is reported.
Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase‐1 Using Pharmacophore Models
- J. Bauer, B. Waltenberger, O. Werz
- Biology, ChemistryChemMedChem
- 1 December 2012
Virtual screening using validated pharmacophore models identified lichen depsides and depsidones as potential inhibitors of mPGES-1, an emerging target for NSAIDs, indicating that these natural products have potential as novel anti-inflammatory agents.
Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists
- T. Kaserer, Theresa Steinacher, M. Spetea
- BiologyScientific Reports
- 14 August 2020
Corydine and corydaline were identified as G protein-biased agonists to the MOR without inducing β-arrestin2 recruitment upon receptor activation, and represent valuable starting points for future chemical optimization towards the development of novel opioid analgesics, which may exhibit improved therapeutic profiles.
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