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Discovery and resupply of pharmacologically active plant-derived natural products: A review
While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future. Expand
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
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Plant extracts and natural compounds used against UVB-induced photoaging
This review summarized the most current and relevant information concerning plant extracts and natural compounds that are able to protect or mitigate the deleterious effects caused by photoaging in different experimental models. Expand
Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo
The characterization of the natural product plumericin as a highly potent inhibitor of the NF‐κB pathway with a novel chemical scaffold, which was isolated from extracts of Himatanthus sucuuba, an Amazonian plant traditionally used to treat inflammation‐related disorders is reported. Expand
Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders.
The present review aims to serve as an "opening" of this special issue of Molecules, presenting key historical developments, recent advances, and future perspectives outlining the potential of natural products for prevention or therapy of cardiovascular and metabolic disease. Expand
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
It is shown that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses. Expand
Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin
The results indicated that prolonged TNFα exposure could have detrimental consequences to endothelial cells by causing senescence and, therefore, chronically increased TNF α levels might possibly contribute to the pathology of chronic inflammatory diseases by driving premature endothelialsenescence. Expand
Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase‐1 Using Pharmacophore Models
Virtual screening using validated pharmacophore models identified lichen depsides and depsidones as potential inhibitors of mPGES-1, an emerging target for NSAIDs, indicating that these natural products have potential as novel anti-inflammatory agents. Expand
Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.
Results showed that the affinity of tocotrienol analogues to microsomal prostaglandin E2 synthase-1 most probably contributes to the anti-inflammatory potential of this class of derivatives. Expand
Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers--an in vitro model for intestinal absorption.
The findings support the general understanding that the laxative effects of Senna are explainable mainly by metabolites and not by the natively present dianthrones. Expand