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Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.
- Y. Freund-Levi, M. Eriksdotter-Jönhagen, J. Palmblad
- Medicine, PsychologyArchives of Neurology
- 1 October 2006
Administration of omega-3 fatty acid in patients with mild to moderate AD did not delay the rate of cognitive decline according to the MMSE or the cognitive portion of the Alzheimer Disease Assessment Scale, and positive effects were observed in a small group of patients with very mild AD.
Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome.
These results reveal important isomer-specific metabolic actions of CLA in abdominally obese humans and provide physiological insights into the role of specific dietary fatty acids as modulators of insulin resistance in humans.
Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
A change of the proportions of dietary fatty acids, decreasing saturated fatty acid and increasing monounsaturated fatty acid, improves insulin sensitivity but has no effect on insulin secretion.
Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus.
Desaturation and Elongation of Fatty Acids and Insulin Action
- B. Vessby, I. Gustafsson, S. Tengblad, M. Boberg, A. Andersson
- BiologyAnnals of the New York Academy of Sciences
- 1 June 2002
The strong relationships between the Δ5 desaturase activity, a high content of long‐chain polyunsaturated fatty acids in the skeletal muscle, and insulin sensitivity may be due to parallel effects of diet and/or physical activity on the fatty acid composition and on insulin sensitivity.
Conjugated linoleic acid supplementation in humans—metabolic effects
It is suggested that supplementation with CLA may reduce the proportion of body fat in humans and that CLA affects fatty acid metabolism.
Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance
- U. Risérus, S. Basu, S. Jovinge, G. N. Fredrikson, J. Ärnlöv, B. Vessby
- Medicine, BiologyCirculation
- 8 October 2002
The oxidative stress seems closely related to induced insulin resistance, suggesting a link between the fatty acid-induced lipid peroxidation seen in the present study and insulin resistance.
Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study.
- E. Warensjö, J. Sundström, B. Vessby, T. Cederholm, U. Risérus
- MedicineThe American journal of clinical nutrition
- 1 July 2008
Altered endogenous FA desaturation might contribute to mortality risk because it is observed independent associations between desaturase activity indexes and mortality.
Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men.
- U. Risérus, B. Vessby, J. Árnlöv, S. Basu
- MedicineAmerican Journal of Clinical Nutrition
- 1 August 2004
A CLA preparation containing the purified c9,t11 CLA isomer increased insulin resistance and lipid peroxidation compared with placebo in obese men, and the present results should be confirmed in larger studies that also include women.
Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients.
A diet characterized by low-GI starchy foods lowers the glucose and insulin responses throughout the day and improves the lipid profile and capacity for fibrinolysis, suggesting a therapeutic potential in diabetes.