• Publications
  • Influence
Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes.
TLDR
Based on the ligand-linked conformational changes discovered by crystallography, the pathways of the reactions with O2 and NO provide a framework that may account for the involvement of Ngb in controlling the activation of a protective signaling mechanism. Expand
The structure of ActVA‐Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis
TLDR
This is the first crystal structure of an enzyme involved in the tailoring of a type II aromatic polyketide and illustrates some of the enzyme–substrate recognition features that may apply to a range of other enzymes involved in modifying apolyketide core structure. Expand
The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication
TLDR
The conserved structural determinants of this site may provide a framework for attempting to design antiviral drugs to interfere with the infectious nidovirus life cycle. Expand
Complex landscape of protein structural dynamics unveiled by nanosecond Laue crystallography
TLDR
It is proposed that the extended relaxation of the globin moiety reflects reequilibration among conformational substates known to play an essential role in controlling protein function. Expand
Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography.
TLDR
Subnanosecond time-resolved Laue diffraction data on the triple mutant YQR-Mb depict the sequence of structural events associated with heme and protein relaxation from 100 ps to 316 ns and above, suggesting that the internal structure controls the rate and amplitude of the relaxation events. Expand
Free energy of burying hydrophobic residues in the interface between protein subunits.
We have obtained an experimental estimate of the free energy change associated with variations at the interface between protein subunits, a subject that has raised considerable interest since theExpand
Photoconvertible Fluorescent Protein EosFP: Biophysical Properties and Cell Biology Applications
TLDR
A variety of applications in cellular imaging, developmental biology and automated high-content screening applications are presented, which demonstrate that EosFP is a powerful tool for in vivo monitoring of cellular processes. Expand
Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus.
TLDR
The structural basis of specific lesion recognition, the initial step in DNA repair, is explored, describing how the N-terminal subdomain pocket of archaeal DNA polymerases could allow specific recognition of deaminated bases such as uracil and hypoxanthine in addition to the typical DNA bases. Expand
Molecular dynamics simulation of deoxy and carboxy murine neuroglobin in water.
TLDR
The heme sliding motion, the topological reorganization of the internal cavities, the dynamics of the distal histidine, and particularly the conformational change of the CD loop, whose flexibility depends ligand binding are characterized. Expand
The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity.
TLDR
The x-ray structure of CO-bound ferrous murine Ngb at 1.7 A and a comparison with the 1.5-A structure of ferric bis-histidine Ngb are presented, revealing a heme-sliding mechanism of affinity control that may be of significance to understanding Ngb's role in the pathophysiology of the brain. Expand
...
1
2
3
4
5
...