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Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT1A receptor agonist
Background and purpose:  Activation of post‐synaptic 5‐HT1A receptors may provide enhanced therapy against depression. We describe the signal transduction profile of F15599, a novel 5‐HT1A receptorExpand
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Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
We report the discovery of F 13640 and evidence suggesting this agent to produce powerful, broad-spectrum analgesia by novel molecular and neuroadaptative mechanisms. F 13640 stimulatesExpand
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F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
F15599 is a novel agonist with high selectivity and efficacy at serotonin 5-HT(1A) receptors (5-HT(1A)Rs). In signal transduction, electrophysiological and neurochemical tests, F15599 preferentiallyExpand
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Curative resection for left colonic carcinoma: Hemicolectomy vs. Segmental colectomy
PURPOSE: This study was developed to compare median and actuarial survival after left hemicolectomyvs.left segmental colectomy. METHODS: Between January 1980 and January 1985, 270 consecutiveExpand
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High-efficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity.
We report the discovery of novel 5-HT1A receptor agonists and describe the process that led to the antidepressant candidate 9 (F 15599). 9 has nanomolar affinity for 5-HT1A binding sites and is overExpand
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Hemodynamic and biochemical monitoring during major liver resection with use of hepatic vascular exclusion.
Twenty-four resections under hepatic vascular exclusion (HVE) have been performed in patients with massive liver tumors. The procedure of HVE was used to minimize blood loss and the chance of gasExpand
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5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
To examine further the hypothesis that the magnitude of the intrinsic activity of agonists at 5-HT1A receptors determines the magnitude of their psychotropic activity, we studied the relationshipExpand
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Cholecystocholedocholithiasis: a case–control study comparing the short- and long-term outcomes for a “laparoscopy-first” attitude with the outcome for sequential treatment (systematic endoscopic
BackgroundNo unanimous consensus has been achieved regarding the ideal management of cholecystocholedocholithiasis. The treatment of gallbladder and common bile duct (CBD) stones may be achievedExpand
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[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging
PurposeThe serotonin-1A (5-HT1A) receptor is implicated in the pathophysiology of major neuropsychiatric disorders. Thus, the functional imaging of 5-HT1A receptors by positron emission tomographyExpand
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Sodium late current blockers in ischemia reperfusion: is the bullet magic?
We describe the discovery of the first selective, potent, and voltage-dependent inhibitor of the late current mediated by the cardiac sodium channel Na V1.5. The compound 3,4-dihydro- N-[(2Expand
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