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Understanding follicle growth in vivo.
A thorough understanding of the molecular aspects of folliculogenesis is of paramount importance in the context of translational medicine and future clinical applications in human reproduction.
Maternal methylation imprints on human chromosome 15 are established during or after fertilization
It is reported that sperm DNA from two males with an IC deletion had a normal paternal methylation pattern along 15q11–q13, and CpG-rich regions in SNURF-SNRPN and NDN, which in somatic tissues are methylated on the maternal allele, are hypomethylated in unfertilized human oocytes.
Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection.
- B. Balaban, B. Urman, A. Sertac, C. Alataş, S. Aksoy, R. Mercan
- BiologyHuman reproduction
- 1 December 1998
In couples undergoing ICSI, abnormal oocyte morphology is not associated with a decreased fertilization rate or unfavourable embryo quality, and embryosderived from abnormal oocytes yield similar clinical pregnancy and implantation rates when transferred compared with embryos derived from normal oocytes.
Clinical outcome of intracytoplasmic injection of spermatozoa morphologically selected under high magnification: a prospective randomized study.
Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial.
Observed relative increase by 30% in live birth rates with LMWH may be regarded as a clinically significant trend necessitating further research on the use of empirical LMWH in women with RIF and possibly in all women undergoing assisted reproduction treatment.
Effect of oocyte morphology on embryo development and implantation.
The effect of pronuclear morphology on embryo quality parameters and blastocyst transfer outcome.
The results indicate that the pronuclear pattern of the zygote is closely related to blastocyst formation and quality and blastocysts derived from 0 PN zygotes have a higher potential for implantation.
A randomized controlled study of human Day 3 embryo cryopreservation by slow freezing or vitrification: vitrification is associated with higher survival, metabolism and blastocyst formation.
Analysis of metabolism revealed that vitrification had less impact on the metabolic rate of the embryo than freezing, which was reflected in higher survival rate and subsequent development in vitro, and is, therefore, a more effective means of cryopreserving the human embryo than conventional slow freezing.
A comparison of four different techniques of assisted hatching.
- B. Balaban, B. Urman, C. Alataş, R. Mercan, A. Mumcu, A. Isiklar
- Medicine, BiologyHuman reproduction
- 1 May 2002
Comparing retrospectively the efficacy of Ass hatching performed with four different methods in patients undergoing IVF or ICSI yields similar implantation and pregnancy rates.
GnRH agonist protocol administration in the luteal phase in ICSI-ET cycles stimulated with the long GnRH agonist protocol: a randomized, controlled double blind study.
Single 0.1 mg triptorelin administration 6 days after ICSI following ovarian stimulation with the long GnRH agonist protocol does not seem to result in an increase >or=12% in ongoing pregnancy rates.