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The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.
The findings suggest that psychological and pathological indices are closely related to one another, possibly through their common association with the underlying degenerative process in the brain. Expand
Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11, 205–242; (1968) 7, 331–356
This is a series in which key papers in old age psychiatry are presented with an introduction, commentary by the original author and current update by someone working in the field. A fullExpand
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
The results suggest a close relation between changes in the cholinergic system and Alzheimer's dementia, but the precise role of the system in this disease remains to be elucidated. Expand
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
In Parkinson's but not Alzheimer's disease the decrease in neocortical (particularly temporal) choline acetyltransferase correlated with the number of neurons in the nucleus of Meynert suggesting that primary degeneration of these cholinergic neurons may be related, directly or indirectly, to declining cognitive function in Parkinson's disease. Expand
A significant positive correlation between the butyrylcholinesterase activities with increasing age (60–90 years) was found in the hippocampus, and the possible connection between cholinergic system pathology and these cholinestersterase abnormalities in Alzheimer dementia is discussed. Expand
The numbers of limb motor neurons in the human lumbosacral cord throughout life
No evidence exists of loss of motor neurons up to the age of 60 years, but beyond that age, although individual counts vary considerably, there is increasing evidence of a diminishing motor neuron pupulation. Expand
Observations on the brains of non-demented old people.
Findings must be borne in mind when interpreting the changes in the brains of demented old people, or in the investigation of any other central nervous system disorder in old age. Expand
Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants
Monoclonal antibodies are used to show here that neurofilament antigens are present in neurofibrillary tangles, a prominent feature in the pyramidal cells of the hippocampus and in neurones of the cerebral cortex of people suffering from senile dementia of the Alzheimer type. Expand
Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases
Observations, together with major differences in the neuropathology of the nucleus in SDAT and Parkinson's disease (neurofibrillary tangle and Lewy body formation, respectively) suggest that the involvement of the cholinergic system may differ in the two disease processes. Expand
Cell loss in the locus coeruleus in senile dementia of Alzheimer type
Sample counts of the pigmented cells of the locus coeruleus (LC) were performed in 10 middle-aged and 15 old people considered to be intellectually well preserved and in 15 cases of senile dementiaExpand