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OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine
- Zhi-jun Wang, O. Yin, B. Tomlinson, M. Chow
- Biology, Medicine
- Pharmacogenetics and genomics
- 1 July 2008
The study results demonstrated for the first time the existence of genetic polymorphisms of OCT2 in the Chinese population, and showed that the 808G>T polymorphism is associated with a reduced metformin renal or tubular clearance. Expand
The beneficial effects of Tai Chi Chuan on blood pressure and lipid profile and anxiety status in a randomized controlled trial.
- J. Tsai, Wei-Hsin Wang, +6 authors Ju-Chi Liu
- Journal of alternative and complementary medicine
- 1 October 2003
Tai Chi could be used as an alternative modality in treating patients with mild hypertension, with a promising economic effect and under well-designed conditions, Tai Chi exercise training could decrease blood pressure and results in favorable lipid profile changes and improve subjects' anxiety status. Expand
Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole.
The results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole. Expand
Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation.
The hypothesis that PsA may be associated with obesity, hypertension, dyslipidaemia and insulin resistance because of the shared inflammatory pathway is supported. Expand
Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis
Assessment of the in vivo TNF-α-mediated regulation of insulin resistance and lipids levels in rheumatoid arthritis found infliximab improves insulin sensitivity and alters lipid profile in patients with active RA. Expand
The effects of nasal continuous positive airway pressure on platelet activation in obstructive sleep apnea syndrome.
OSAS, through repeated episodes of arousals, may lead to platelet activation, which can be reduced by nasal CPAP therapy, which is confirmed by univariate analysis of variance. Expand
A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension.
- P. Chan, B. Tomlinson, Y. J. Chen, J. C. Liu, M. Hsieh, J. Cheng
- British journal of clinical pharmacology
- 1 September 2000
This study shows that oral stevioside is a well tolerated and effective modality that may be considered as an alternative or supplementary therapy for patients with hypertension. Expand
Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
In this 2-year study in Chinese patients with mild hypertension, oral stevioside significantly decreased SBP and DBP compared with placebo, and QOL was improved, and no significant adverse effects were noted. Expand
Subclinical carotid atherosclerosis in patients with psoriatic arthritis.
PsA is associated with subclinical atherosclerosis after adjusting for traditional CV risk factors, and carotid IMT can identify PsA patients with sub Clinical Atherosclerosis who may benefit from early intervention. Expand
Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention
Population-based long-term follow-up studies are urgently needed to demonstrate the association of risk factors with hypertension in Asia, and prevention programmes should be started based on cross-sectional surveys and case studies without waiting for the cohort studies. Expand