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Acute respiratory distress syndrome: the Berlin Definition.
TLDR
The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
TLDR
The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system was used to guide assessment of quality of evidence from high to very low and to determine the strength of recommendations.
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.
TLDR
Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS.
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
TLDR
In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
TLDR
In patients with acute lung injury and ARDS who receive mechanical ventilation with a tidal-volume goal of 6 ml per kilogram of predicted body weight and an end-inspiratory plateau-pressure limit of 30 cm of water, clinical outcomes are similar whether lower or higher PEEP levels are used.
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material
TLDR
This panel addressed some of the limitations of the prior ARDS definition by incorporating current data, physiologic concepts, and clinical trials results to develop the Berlin definition, which should facilitate case recognition and better match treatment options to severity in both research trials and clinical practice.
Comparison of two fluid-management strategies in acute lung injury.
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.
TLDR
Methylprednisolone increased the number of ventilator-free and shock-free days during the first 28 days in association with an improvement in oxygenation, respiratory-system compliance, and blood pressure with fewer days of vasopressor therapy and did not increase the rate of infectious complications but was associated with a higher rate of neuromuscular weakness.
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