• Publications
  • Influence
Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
McNaught and colleagues 1 reported recently that systemic administration of proteasome inhibitors PSI (Z‐Ileu‐Glu(OtBu)‐Ala‐Leu‐CHO) or epoxomicin recapitulated many of the degenerative changes seenExpand
Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is efficacious in treating the motor symptoms of Parkinson's disease (PD). However, the impact of STN-DBS on the progression of PD isExpand
Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
Multiple laboratories have recently demonstrated that long-term dopaminergic transplants form Lewy bodies in patients with Parkinson's disease. Debate has arisen as to whether these Lewy bodies formExpand
3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in culture
The current study examined whether modest concentrations of MDMA could increase the survival and/or neurite outgrowth of fetal midbrain dopamine (DA) neurons in vitro since increased DA neuriteExpand
Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons
The poor survival rate (5-20%) of grafted embryonic dopamine (DA) neurons is one of the primary factors preventing cell replacement from becoming a viable treatment for Parkinson's disease. PreviousExpand
Effects of short-term concentric vs. eccentric resistance training on single muscle fiber MHC distribution in humans.
The purpose of this investigation was to determine the effects of a concentric vs. eccentric resistance training program on single muscle fiber myosin heavy chain (MHC) adaptations in humans. FifteenExpand
Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system
In addition to alleviating depression, trophic responses produced by antidepressants may regulate neural plasticity in the diseased brain, which not only provides symptomatic benefit but alsoExpand
Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model.
Neurotrophic factors are integrally involved in the development of the nigrostriatal system and in combination with gene therapy, possess great therapeutic potential for Parkinson's disease (PD).Expand
Chronic Amitriptyline Treatment Attenuates Nigrostriatal Degeneration and Significantly Alters Trophic Support in a Rat Model of Parkinsonism
In addition to alleviating depression, long-term adaptive changes induced by antidepressants may regulate neural plasticity in the diseased brain, providing symptomatic and disease-modifying effectsExpand
Prenatal exposure to MDMA alters noradrenergic neurodevelopment in the rat.
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) binds with high affinity to the norepinephrine transporter (NET), making the noradrenergic system a potential target during fetal exposure. RecentExpand