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Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons
TLDR
The co-localization of two Shaker-like voltage-gated K+-channel proteins is described, indicating that the two polypeptides occur in subcellular regions where rapid membrane repolarization may be important and that they form heteromultimeric channels in vivo. Expand
Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain
TLDR
It is shown that two closely related voltage- gated potassium channel proteins, mKv1.1 and mKV1.2, are present in multiple subcellular locations including cell somata, juxta-paranodal regions of myelinated axons, synaptic terminals, unmyelinatedAxons, specialized junctions among axon, and proximal dendrites. Expand
Reward learning in normal and mutant Drosophila.
Hungry fruit flies can be trained by exposing them to two chemical odorants, one paired with the opportunity to feed on 1 M sucrose. On later testing, when given a choice between odorants the fliesExpand
Deletion of the KV1.1 Potassium Channel Causes Epilepsy in Mice
TLDR
Axonal action potential conduction was altered as well in the sciatic nerve--a deficit potentially related to the pathophysiology of episodic ataxia/myokymia, a disease associated with missense mutations of the human K(V)1.1 gene. Expand
Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.
TLDR
Two of the complementary DNA clones have been sequenced and their sequences support the hypothesis that Shaker encodes a component of a K+ channel, the A channel of Drosophila melanogaster. Expand
The consequences of disrupting cardiac inwardly rectifying K+ current (IK1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes
TLDR
The Kir2.1‐/‐ mouse provides a model in which the functional consequences of removing IK1 can be studied at both cellular and organismal levels, and is the major component of murine IK 1 and the Kir1.1 outside the heart. Expand
Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons.
TLDR
Surprisingly, MNTB neurons in brain stem slices from -/- and +/- mice were hypoexcitable despite their Kcna2 deficit, and voltage-clamped -/- MNTBs neurons had enlarged I Kv1.2 activated at abnormally negative potentials, which may explain why M NTB neurons with larger proportions of such channels had larger I KV1.1 channels. Expand
Differential expression of voltage-gated potassium channel genes in auditory nuclei of the mouse brainstem
Voltage-gated potassium (Kv) channels may play an important role in the encoding of auditory information. Towards understanding the roles of Shaker and Shaw-like channels in this process, we examineExpand
The Type 1 Inositol 1,4,5-Trisphosphate Receptor Gene Is Altered in the opisthotonos Mouse
TLDR
The genetic and molecular data presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, which serves as an IP3-gated channel to release calcium from intracellular stores, is altered in the optmutant, suggesting that the convulsions and ataxia observed in opt mice may be caused by the physiological dysregulation of a functional IP3R 1 protein. Expand
Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice
TLDR
These mutations affecting Atp2b2 in dfw and dfw2J are the first to be found in a mammalian plasma membrane calcium pump and define a new class of deafness genes that directly affect hair-cell physiology. Expand
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