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Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones.
Five single-point aquaporin-2 (AQP2) mutations that cause non-X-linked nephrogenic diabetes insipidus (NDI) were characterized to establish the cellular defect and to develop therapeutic strategies.… Expand
Water transport across mammalian cell membranes.
- A. Verkman, A. V. Van Hoek, +5 authors J. Fariñas
- Biology, Materials Science
- The American journal of physiology
This review summarizes recent progress in water-transporting mechanisms across cell membranes. Modern biophysical concepts of water transport and new measurement strategies are evaluated. A family of… Expand
Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.
- S. Shafqat, B. Tamarappoo, +4 authors R. T. Fremeau
- Biology, Medicine
- The Journal of biological chemistry
- 25 July 1993
A cDNA has been isolated from human hippocampus that appears to encode a novel Na(+)-dependent, Cl(-)-independent, neutral amino acid transporter. The putative protein, designated SATT, is 529 amino… Expand
Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events.
OBJECTIVES We aimed to evaluate whether pericardial fat has value in predicting the risk of future adverse cardiovascular outcomes. BACKGROUND Pericardial fat volume (PFV) and thoracic fat volume… Expand
Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT.
OBJECTIVES We evaluated the association between pericardial fat and myocardial ischemia for risk stratification. BACKGROUND Pericardial fat volume (PFV) and thoracic fat volume (TFV) measured from… Expand
Computer-aided non-contrast CT-based quantification of pericardial and thoracic fat and their associations with coronary calcium and Metabolic Syndrome.
INTRODUCTION Pericardial fat is emerging as an important parameter for cardiovascular risk stratification. We extended previously developed quantitation of thoracic fat volume (TFV) from non-contrast… Expand
Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response.
- M. C. Canfield, B. Tamarappoo, A. Moses, A. Verkman, E. Holtzman
- Biology, Medicine
- Human molecular genetics
- 1 October 1997
Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused most often by mutations in the vasopressin V2 receptor (AVPR2). We studied a family which included a female patient with NDI… Expand
Prognostic Value of Combined Clinical and Myocardial Perfusion Imaging Data Using Machine Learning.
- Julian Betancur, Yuka Otaki, +9 authors P. Slomka
- JACC. Cardiovascular imaging
- 18 October 2017
OBJECTIVES This study evaluated the added predictive value of combining clinical information and myocardial perfusion single-photon emission computed tomography (SPECT) imaging (MPI) data using… Expand
Vasopressin regulated trafficking of a green fluorescent protein-aquaporin 2 chimera in LLC-PK1 cells
- C. E. Gustafson, S. Levine, +5 authors D. Brown
- Biology, Medicine
- Histochemistry and Cell Biology
- 14 September 1998
Abstract Aquaporin 2 (AQP2) transfected into LLC-PK1 cells functions as a vasopressin-regulated water channel that recycles between intracellular vesicles and the plasma membrane upon vasopressin… Expand
Clinical features associated with adverse events in patients with post-pericardiotomy syndrome following cardiac surgery.
- M. C. Alraies, W. AlJaroudi, C. Shabrang, H. Yarmohammadi, A. Klein, B. Tamarappoo
- The American journal of cardiology
- 1 November 2014
Postpericardiotomy syndrome (PPS) may be associated with tamponade and pericardial constriction that may require procedural intervention. The aim of this study was to identify clinical features… Expand