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Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones.
Five single-point aquaporin-2 (AQP2) mutations that cause non-X-linked nephrogenic diabetes insipidus (NDI) were characterized to establish the cellular defect and to develop therapeutic strategies.Expand
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Water transport across mammalian cell membranes.
This review summarizes recent progress in water-transporting mechanisms across cell membranes. Modern biophysical concepts of water transport and new measurement strategies are evaluated. A family ofExpand
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Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.
A cDNA has been isolated from human hippocampus that appears to encode a novel Na(+)-dependent, Cl(-)-independent, neutral amino acid transporter. The putative protein, designated SATT, is 529 aminoExpand
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Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events.
OBJECTIVES We aimed to evaluate whether pericardial fat has value in predicting the risk of future adverse cardiovascular outcomes. BACKGROUND Pericardial fat volume (PFV) and thoracic fat volumeExpand
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Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT.
OBJECTIVES We evaluated the association between pericardial fat and myocardial ischemia for risk stratification. BACKGROUND Pericardial fat volume (PFV) and thoracic fat volume (TFV) measured fromExpand
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Computer-aided non-contrast CT-based quantification of pericardial and thoracic fat and their associations with coronary calcium and Metabolic Syndrome.
INTRODUCTION Pericardial fat is emerging as an important parameter for cardiovascular risk stratification. We extended previously developed quantitation of thoracic fat volume (TFV) from non-contrastExpand
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Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response.
Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused most often by mutations in the vasopressin V2 receptor (AVPR2). We studied a family which included a female patient with NDIExpand
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Prognostic Value of Combined Clinical and Myocardial Perfusion Imaging Data Using Machine Learning.
OBJECTIVES This study evaluated the added predictive value of combining clinical information and myocardial perfusion single-photon emission computed tomography (SPECT) imaging (MPI) data usingExpand
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Vasopressin regulated trafficking of a green fluorescent protein-aquaporin 2 chimera in LLC-PK1 cells
Abstract Aquaporin 2 (AQP2) transfected into LLC-PK1 cells functions as a vasopressin-regulated water channel that recycles between intracellular vesicles and the plasma membrane upon vasopressinExpand
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Clinical features associated with adverse events in patients with post-pericardiotomy syndrome following cardiac surgery.
Postpericardiotomy syndrome (PPS) may be associated with tamponade and pericardial constriction that may require procedural intervention. The aim of this study was to identify clinical featuresExpand
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