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Rethinking equine gastric ulcer syndrome: Part 1 – Terminology, clinical signs and diagnosis
Summary Equine gastric ulcer syndrome (EGUS) is a common condition in the horse. A series of recent articles highlighting differences in healing of squamous and glandular ulceration have… Expand
Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised, blinded, clinical study
BackgroundInterest in Equine Gastric Ulcer Syndrome (EGUS) has recently increased in part due to a growing awareness of the differences between squamous and glandular disease. The pathophysiology and… Expand
Equine endotoxaemia--a state-of-the-art review of therapy.
The pathophysiology of endotoxaemia, a leading cause of death in the horse, is beginning to be understood in greater detail. Endotoxin may be absorbed into the systemic circulation in a number of… Expand
Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)
Summary It has recently been highlighted that significant differences in prevalence, risk factors and the response to treatment exist between ulceration of the squamous gastric mucosa and… Expand
In vivo pretreatment with PGG-glucan fails to alter cytokine mRNA expression of equine peripheral blood mononuclear cells exposed to endotoxin ex vivo.
Twelve healthy horses were assigned to treatment or control groups. Treated horses received PGG-Glucan[ED-1] (1 mg/kg, IV) 24 hours prior to peripheral blood mononuclear cell (PBMC) isolation. PBMCs… Expand
Pharmacokinetics of intravenous, plain oral and enteric-coated oral omeprazole in the horse.
- B. Sykes, C. Underwood, C. Mcgowan, P. Mills
- Journal of veterinary pharmacology and…
- 1 April 2015
The objectives were to document the pharmacokinetics of intravenous, enteric-coated oral and plain oral omeprazole in fasted horses and to investigate the impact of feeding on the bioavailability of… Expand
A comparison of two doses of omeprazole in the treatment of equine gastric ulcer syndrome: a blinded, randomised, clinical trial.
REASONS FOR PERFORMING THE STUDY Studies on omeprazole have reported that doses as low as 0.7 mg/kg bwt per os are potent suppressors of acid production. Yet, to date, no studies have compared… Expand
A comparison between pre‐ and post exercise administration of omeprazole in the treatment of equine gastric ulcer syndrome: A blinded, randomised, clinical trial
Summary Reasons for performing the study A recent study suggested that the duration of acid suppression achieved with once-daily administration of omeprazole is as short as 12 h and that… Expand
A comparison of the prevalence of gastric ulceration in feral and domesticated horses in the UK.
Equine gastric ulcer syndrome is common in domesticated horses, especially those performing in athletic endeavours. However, the prevalence of equine gastric ulcer syndrome in feral populations of… Expand
Diagnostic evaluation and short-term outcome as indicators of long-term prognosis in horses with findings suggestive of inflammatory bowel disease treated with corticosteroids and anthelmintics
- R. Kaikkonen, Kati Niinistö, B. Sykes, M. Anttila, S. Sankari, M. Raekallio
- Acta Veterinaria Scandinavica
- 3 June 2014
BackgroundRecurrent colic and unexplained weight loss despite good appetite and adequate feeding and management practices are common conditions in the horse. However, little information has been… Expand