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Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2.
Albumin catalyzes the transformation of prostaglandin D2 to 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and to isomeric prostaglandin D2 compounds including delta 12(E)-prostaglandin D2. Both ofExpand
Conjugation of 9-Deoxy-Δ9,Δ12(E)-prostaglandin D2 with Intracellular Glutathione and Enhancement of Its Antiproliferative Activity by Glutathione Depletion
Abstract The major dehydration product of prostaglandin D2, 9-deoxy-Δ9,Δ12(E)-prostaglandin D2, is a potent cytotoxic compound. Like other cytotoxic prostaglandins, this compound possesses anExpand
Prostaglandins as mediators of hypercalcemia associated with certain types of cancer.
We investigated the role of prostaglandins in the hypercalcemia associated with neoplasia. In patients with hypercalcemia and solid tumors the excretion of the major urinary metabolite of the EExpand
Relation between plasma concentration of indomethacin and its effect on prostaglandin synthesis and platelet aggregation in man
The dose and plasma levels of indomethacin correlated with inhibition of prostaglandin synthesis as measured both by urinary excretion of the major metabolite of prostaglandin E2 (PGE‐M) and by theExpand
Low Back Pain: diagnosis, treatment, and prognosis
  • B. Sweetman
  • Medicine
  • Scandinavian journal of rheumatology
  • 1 January 2005
The excellent review by Aage Indahl (1) dealing with all the difficulties associated with distinguishing diagnoses for many if not most cases of low back pain is a timely reminder that littleExpand
Urinary prostaglandins. Identification and origin.
Human urine was analyzed by mass spectrometry for the presence of prostaglandins. Prostaglandin E2 and F2alpha were detected in urine from females by selected ion monitoring of the prostaglandinExpand
Increased production of prostaglandin D2 in patients with systemic mastocytosis.
SYSTEMIC mastocytosis is a disorder of unknown origin, characterized by abnormal proliferation of tissue mast cells involving various organs and associated with a variety of clinical symptoms and s...
Prostaglandin-mediated hypercalcemia in the VX2 carcinoma-bearing rabbit.
Prostaglandin biosynthesis and metabolism were studied in the VX2 carcinoma-bearing rabbit, an animal model of prostaglandin-mediated hypercalcemia. All the identification and quantification of theExpand
Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes.
We have previously demonstrated that procainamide is oxidized to a reactive metabolite. We speculated that this reactive metabolite might be a hydroxylamine and further that it might be responsibleExpand
Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography.
A gas chromatographic method was developed for the determination of the R- and S- enantiomers of the anticonvulsant, mephenytoin, and its N-demethylated metabolite, 5-phenyl-5- ethylhydantoin ( PEHExpand