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Collective total synthesis of englerin A and B, orientalol E and F, and oxyphyllol: application of the organocatalytic [4+3] cycloaddition reaction.
The concise collective total synthesis of englerin A and B, orientalol E and F, and oxyphyllol has been accomplished in 10-15 steps, with the total synthesis of orientalol E and oxyphyllol being… Expand
Concise approach to the core of englerin A via an organocatalytic [4+3] cycloaddition reaction
A concise enantioselective synthesis of diversely functionalized advanced intermediates comprising the tricyclic skeleton of englerin A and related oxygen-bridged guaianes has been successfully… Expand
Total synthesis of natural and pharmaceutical products powered by organocatalytic reactions
- B. Sun
- 22 April 2015
Abstract Organocatalysis has emerged as the third pillar of modern asymmetric catalysis in the past two decades. Applying organocatalytic reactions in total synthesis is currently a highly dynamic… Expand
Pharmaceutical-Oriented Selective Synthesis of Mononitriles and Dinitriles Directly from Methyl(hetero)arenes: Access to Chiral Nitriles and Citalopram.
- J. Liu, Hong-xing Zheng, Chuan-Zhi Yao, B. Sun, Y. Kang
- Chemistry, Medicine
- Journal of the American Chemical Society
- 7 March 2016
A pharmaceutical-oriented, transition-metal-free, cyanide-free one-step direct transformation of methylarenes to aryl nitriles is described. For the dimethylarenes, the selectivity can be… Expand
Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.
- R. Ding, Jian-guo Fu, Guangqiang Xu, B. Sun, Guo-qiang Lin
- Medicine, Chemistry
- The Journal of organic chemistry
- 3 January 2014
Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (= Lycopodium serratum ) in minuscule amounts. The most efficient total synthesis of huperzine… Expand
An efficient total synthesis of (-)-epothilone B.
An efficient total synthesis of (-)-epothilone B has been achieved in ca. 8% yield over 11 steps from 9 (or 10 steps from 7/8), which features a bissiloxane-tethered ring closing metathesis reaction… Expand
Catalytic Asymmetric Total Synthesis of Hedyosumins A, B, and C.
The first and asymmetric total synthesis of hedyosumins A, B, and C was accomplished in 13-14 steps from simple starting materials. The essential tools that allow us to access the tetracyclic… Expand
Asymmetric total synthesis of Lycopodium alkaloids α-obscurine, N-desmethyl-α-obscurine, β-obscurine and N-desmethyl-β-obscurine
The asymmetric total synthesis of α-obscurine (1), β-obscurine (2), N-desmethyl-α-obscurine (3), and N-desmethyl-β-obscurine (4) was accomplished. Key reactions in the construction of the A/B/C-ring… Expand
Concise Formal Synthesis of (+)-Englerin A and Total Synthesis of (-)-Orientalol F: Establishment of the Stereochemistry of the Organocatalytic [4+3]-Cycloaddition Reaction
The enantioselective formal synthesis of (+)-englerin A and the total synthesis of (-)-orientalol F were successfully accomplished via a triene. The success enabled establishment of the relative as… Expand
General synthetic approach to bicyclo[9.3.0]tetradecenone: a versatile intermediate to clavulactone and clavirolides
Abstract An efficient and stereoselective approach to the bicyclo[9.3.0]tetradecenone core structure of clavulactone starting from readily and abundantly available 2-methyl-1,3-cyclopentandione… Expand