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Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study.
TLDR
In this prospective study in a European population, the prevalence and incidence of AF increased with age and were higher in men than in women and the high lifetime risk to develop AF was similar to North American epidemiological data.
Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.
TLDR
Current use of gastric acid-suppressive therapy was associated with an increased risk of community-acquired pneumonia and a significant positive dose-response relationship was observed.
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
TLDR
This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study, and identified eight loci associated with FEV1/FVC and one locus at or near genome-wide significance in theCHARGE Consortium dataset.
Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences.
TLDR
A considerable proportion of all CVD events could be attributed to poor adherence to vascular medications alone, and that the level of optimal adherence confers a significant inverse association with subsequent adverse outcomes is demonstrated.
Prolonged QTc interval and risk of sudden cardiac death in a population of older adults.
Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060.
TLDR
The number of adults 55 years and over with AF in the European Union will more than double from 2010 to 2060, and this increasing number of individuals with AF may have major public health implications.
Common variants at ten loci influence QT interval duration in the QTGEN Study
TLDR
A meta-analysis of three genome-wide association studies in 13,685 individuals of European ancestry offers insights into myocardial repolarization and suggests candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias.
Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE‐AF Consortium
TLDR
A risk model including variables readily available in primary care settings adequately predicted atrial fibrillation in diverse populations from the United States and Europe.
Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors
TLDR
The genetic urate score analysis suggested a causal relationship between serum urate and gout but did not provide evidence for one between serum Urate and cardiovascular risk factors and coronary heart disease (CHD).
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