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Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study.
AIMS We aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in a large European population-based study. METHODS AND RESULTS The study is part of the Rotterdam study, aExpand
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Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study.
AIMS To determine the prevalence, incidence rate, lifetime risk and prognosis of heart failure. METHODS AND RESULTS The Rotterdam Study is a prospective population-based cohort study in 7983Expand
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Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.
CONTEXT Reduction of gastric acid secretion by acid-suppressive therapy allows pathogen colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated stomach haveExpand
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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinicallyExpand
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Common variants at ten loci influence QT interval duration in the QTGEN Study
QT interval duration, reflecting myocardial repolarization on the electrocardiogram, is a heritable risk factor for sudden cardiac death and drug-induced arrhythmias. We conducted a meta-analysis ofExpand
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Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences.
AIMS The aim of this study was to determine the extent to which adherence to individual vascular medications, assessed by different methods, influences the absolute and relative risks (RRs) ofExpand
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Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variantsExpand
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C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study.
PURPOSE It remains unclear if inflammation itself may induce cancer, if inflammation is a result of tumor growth, or a combination of both exists. The aim of this study was to examine whetherExpand
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The Rotterdam Study: 2014 objectives and design update
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic,Expand
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Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives
OBJECTIVE Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult toExpand
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