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A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many differentExpand
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  • Open Access
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iteratesExpand
  • 1,337
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  • Open Access
Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels*
TRPM2 is a member of the transient receptor potential melastatin-related (TRPM) family of cation channels, which possesses both ion channel and ADP-ribose hydrolase functions. TRPM2 has been shown toExpand
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The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target
Wrapped DNA TAL effectors are proteins that bacterial pathogens inject into plant cells that bind to host DNA to activate expression of plant genes. The DNA-binding domain of TAL proteins is composedExpand
  • 430
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  • Open Access
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
BACKGROUND Yeast pyruvate kinase (PK) catalyzes the final step in glycolysis. The enzyme therefore represents an important control point and is allosterically activated by fructose-1,6-bisphosphateExpand
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Homing endonuclease structure and function.
  • B. Stoddard
  • Medicine, Biology
  • Quarterly reviews of biophysics
  • 9 February 2006
Homing endonucleases are encoded by open reading frames that are embedded within group I, group II and archael introns, as well as inteins (intervening sequences that are spliced and excisedExpand
  • 379
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De Novo Computational Design of Retro-Aldol Enzymes
The creation of enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Using new algorithms that rely on hashing techniques to constructExpand
  • 882
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  • Open Access
Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme
The crystal structure of an unmodified hammerhead RNA in the absence of divalent metal ions has been solved, and it was shown that this ribozyme can cleave itself in the crystal when divalent metalExpand
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  • Open Access
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
Biocatalytic Boost Enzymes tend to direct reactions toward specific products much more selectively than synthetic catalysts. Unfortunately, this selectivity has evolved for cellular purposes and mayExpand
  • 630
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  • Open Access
Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility.
Homing endonucleases confer mobility to their host intervening sequence, either an intron or intein, by catalyzing a highly specific double-strand break in a cognate allele lacking the interveningExpand
  • 422
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  • Open Access