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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
The architecture of human chromosomes in interphase nuclei is still largely unknown. Microscopy studies have indicated that specific regions of chromosomes are located in close proximity to theExpand
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Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells
Chromatin is important for the regulation of transcription and other functions, yet the diversity of chromatin composition and the distribution along chromosomes are still poorly characterized. ByExpand
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TRF2 Protects Human Telomeres from End-to-End Fusions
The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here, we show that the human telomeric protein TRF2 plays a key role in the protective activity of telomeres. AExpand
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Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)
The spatial organization of DNA in the cell nucleus is an emerging key contributor to genomic function. We developed 4C technology (chromosome conformation capture (3C)-on-chip), which allows for anExpand
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Characterization of the Drosophila melanogaster genome at the nuclear lamina
The nuclear lamina binds chromatin in vitro and is thought to function in its organization, but genes that interact with it are unknown. Using an in vivo approach, we identified ∼500 DrosophilaExpand
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Single-Cell Dynamics of Genome-Nuclear Lamina Interactions
The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina associated domains (LADs). The dynamics of these interactions and the relation to epigenetic modifications areExpand
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Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase
We have developed a novel technique, named DamID, for the identification of DNA loci that interact in vivo with specific nuclear proteins in eukaryotes. By tethering Escherichia coli DNA adenineExpand
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Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster
Polycomb group (PcG) proteins maintain transcriptional repression of developmentally important genes and have been implicated in cell proliferation and stem cell self-renewal. We used a genome-wideExpand
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Detection of in vivo protein–DNA interactions using DamID in mammalian cells
Understanding gene regulatory networks in mammalian cells requires detailed knowledge of protein–DNA interactions. Commonly used methods for genome-wide mapping of these interactions are based onExpand
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Control of telomere length by the human telomeric protein TRF1
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific proteins. In normal human cells, telomeres shorten with successive cellExpand
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